Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (4): 907-912    DOI: 10.31083/j.ceog4804143
Special Issue: Uterus Transplantation: current evidences, open questions and future directions
Original Research Previous articles | Next articles
Diminished ovarian reserve and ectopic ovaries in patients with Mayer-Rokitansky-Küster-Hauser syndrome candidates for Uterus Transplantation: our experience
Basilio Pecorino1, *(), Giuseppe Scibilia1, Placido Borzì1, Maria Elena Vento1, Pierfrancesco Veroux2, Paolo Scollo1
1Gynecology and Obstetrics Units, Maternal and Child Department, Cannizzaro Hospital, 95126 Catania, Italy
2Vascular Surgery and Organ Transplant Unit, Department of Medical and Surgical Sciences, University Hospital of Catania, 95123 Catania, Italy
Download:  PDF(2161KB)  ( 53 ) Full text   ( 5 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Background: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disease characterized by variable degrees of utero-vaginal agenesis. A diminished ovarian reserve and ectopic ovaries are common in these patients. The objective of this study is to highlight the issues relating to assisted reproduction in patients with MRKH syndrome who are candidates for Uterus Transplantation and to describe alternative methods to the classic transvaginal oocyte retrieval. Methods: In Italy, the Research Project for Uterus Transplantation from brain-dead donor started on 14/06/2018 (n. 1438/CNT2018). The potential recipients underwent to clinical evaluation, laboratory and instrumental tests to achieve eligibility for transplantation, ovarian stimulation and oocytes retrieval at the Obstetrics and Gynecology Unit of the Cannizzaro Hospital of Catania (Italy). A retrospective analysis of all patients affected by MRKH syndrome who are candidates for uterus transplantation was performed in order to highlight the problems encountered in assisted reproduction due to poor ovarian reserve or extra-pelvic gonads. Results: 15 of 64 patients (23%) were excluded after the first visit due to the poor ovarian reserve and/or ectopic ovaries. A 27-years old patient with MRKH syndrome type 2, with extra-pelvic ovaries and good ovarian reserve underwent ultrasound-guided and laparoscopically assisted transvaginal and transabdominal oocyte pick-up, with total retrieval of 12 oocytes and no short or long-term complications. Conclusion: Laparoscopically assisted oocyte retrieval is a feasible technique that can overcome some limitations for inclusion on waiting list for Uterus Transplantation, such as ectopic ovaries.
Key words:  Assisted reproduction      Laparoscopy      MRKH syndrome      Oocyte pick-up      Uterus transplantation     
Submitted:  31 March 2021      Revised:  16 April 2021      Accepted:  17 May 2021      Published:  15 August 2021     
*Corresponding Author(s):  Basilio Pecorino     E-mail:  eliopek@gmail.com

Cite this article: 

Basilio Pecorino, Giuseppe Scibilia, Placido Borzì, Maria Elena Vento, Pierfrancesco Veroux, Paolo Scollo. Diminished ovarian reserve and ectopic ovaries in patients with Mayer-Rokitansky-Küster-Hauser syndrome candidates for Uterus Transplantation: our experience. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 907-912.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4804143     OR     https://ceog.imrpress.com/EN/Y2021/V48/I4/907

[1] Ranit Hizkiyahu, Shannon Salvador, Michael H. Dahan. Ovarian stimulation for fertility preservation in a woman with borderline serous ovarian tumor causing a large fluctuating subcutaneous fluid collection: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1215-1218.
[2] Üzeyir Kalkan, Murat Yassa, Kadir Bakay, Şafak Hatırnaz. Mechanical bowel preparation prior to gynaecological laparoscopy enables better operative field visualization, lower pneumoperitoneum pressure and Trendelenburg angle during the surgery: a perspective that may add to patient safety[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 842-850.
[3] Francesco Fedele, Alessandro Bulfoni, Stefano Salvatore, Massimo Candiani. Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 453-460.
[4] Li-Min Zhou, Jie Duan, Yan Yang. Endoscopic treatment with concomitant ultrasound monitoring of obstructive septum in Robert's uterus following pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 711-714.
[5] Engin Turkgeldi, Sule Yildiz, Berk Angun, Bulent Urman, Baris Ata. Oocyte yield of GnRH antagonist cycles scheduled with a short course of estradiol in the early follicular phase[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 278-282.
[6] L.B. Liu, H.T. Sun, S.F. Liu, R.X. Shi. Laparoscopy combined with hysteroscopy for cesarean scar pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 911-914.
[7] M.S. Kim, E.D. Na, H.C. Kim, M. Kim, S.Y. Shin, M.H. Lee. Torsion of a rudimentary uterine horn with multiple leiomyomas in a case of Mayer-Rokitansky-Küster-Hauser syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 968-971.
[8] A. Lavinia Cozlea, E. Előd Élthes, Á. Török, M. Emil Capîlna. Clinical presentation, risk factors and management of ectopic pregnancy: a case-control study[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 914-919.
[9] Y. Wang, F.Y. Luo, Y.D. Xia, L. Mei, L. Xie, H.X. Liu. Clinical analysis of 211 cases of cesarean scar pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 948-952.
[10] R. T. Ratner, A. Harris, J. Tsaltas, N. Goyal, M. Davies-Tuck, H. Najjar, O. Barel. An eight-year retrospective analysis of laparoscopic surgery for endometriosis, outcomes and complications in a large multicenter unit[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 699-703.
[11] A. Pontis, L. Nappi, F. Sorrentino, S. Angioni. Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 511-515.
[12] M. Simonsen, L. Martins Campbell, R. Moretti Marques. Uterine manipulator - low budget option[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 575-577.
[13] N.N. Chavan, R. Deshmukh, N. Raj. An observational study on diagnosis and management of adnexal masses in pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 583-586.
[14] S. Matsuoka, H. Tsujioka, M. Ando, Y. To, T. Koyanagi, H. Kondo, F. Eguchi. Anti-N-methyl-D-aspartate receptor encephalitis associated with a tiny ovarian teratoma diagnosed by exploratory laparoscopy: report of two cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 305-308.
[15] A. Daniilidis, K. Chatzistamatiou, M. Siskou, ü. Kalkan, T. Theodoridis, S. Angioni. Vault prolapse occurrence after total laparoscopic hysterectomy and total abdominal hysterectomy performed for benign indications, is there a difference? A systematic review of the literature[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 183-185.
No Suggested Reading articles found!