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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (4): 893-900    DOI: 10.31083/j.ceog4804141
Original Research Previous articles | Next articles
Obstetric outcomes in women of advanced maternal age after assisted reproduction
Anna M. Rubinshtein1, *(), Oleg V. Golyanovskiy1
1Department of Obstetrics and Gynecology No1, Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine
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Abstract  
Background: Pregnancy and deliveries resulting from assisted reproductive technology (ART) in women of advanced maternal age (AMA) are reported to be associated with adverse maternal and perinatal outcomes. The aim of the study was to investigate the impact of a combination of AMA and assisted reproduction on obstetric and perinatal outcomes of nulliparous singleton pregnancies. Methods: Medical records of 201 live-born singletons, cephalic, non-anomalous nulliparous pregnancies were reviewed retrospectively. The IVF conception (90 AMA women after ART) and spontaneous conception (111 AMA women with spontaneous pregnancy) groups were formed. Results: Intrauterine growth restriction, nonreassuring fetal state, operative vaginal delivery, cesarean section, induction of labor, and massive obstetric hemorrhage were more common in AMA patients after ART compared with the spontaneous conception group. The incidence of preeclampsia and nonreassuring fetal status during pregnancy in the IVF conception group was more than 2 times higher than that in the spontaneous conception group. There were no significant differences in spontaneous preterm delivery, Apgar scores, and neonatal morbidity rates between the study groups. Discussion: Nulliparous AMA women with pregnancies obtained after ART have inherently higher risks of severe adverse maternal and perinatal outcomes and require careful dynamic monitoring of mother's and fetal conditions followed by prevention and, if possible, correction of disorders during pregnancy and delivery.
Key words:  Nulliparity      Pregnancy complication      Adverse maternal outcomes      Adverse perinatal outcomes     
Submitted:  18 January 2021      Revised:  20 April 2021      Accepted:  23 April 2021      Published:  15 August 2021     
*Corresponding Author(s):  Anna M. Rubinshtein     E-mail:  anna.rubinshtein@leleka.com.ua

Cite this article: 

Anna M. Rubinshtein, Oleg V. Golyanovskiy. Obstetric outcomes in women of advanced maternal age after assisted reproduction. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 893-900.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4804141     OR     https://ceog.imrpress.com/EN/Y2021/V48/I4/893

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