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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (3): 670-675    DOI: 10.31083/j.ceog.2021.03.2510
Special Issue: Updates in obstetrics and gynecology
Original Research Previous articles | Next articles
Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting
Gulzhanat Aimagambetova1, Aiym Kaiyrlykyzy2, Gauri Bapayeva3, Talshyn Ukybassova3, Kamila Kenbayeva3, Bakytkali Ibrayimov4, Alla Lyasova5, Giulio Bonaldo6, Giovanni Buzzaccarini6, *(), Marco Noventa6, Antonio Simone Laganà7, Milan Terzic3, 8, 9
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 020000 Nur-Sultan, Kazakhstan
2National Laboratory of Astana, Nazarbayev University, 010000 Nur-Sultan, Kazakhstan
3Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, Kazakhstan
4Department of Pathological Anatomy, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, Kazakhstan
5Pathology bureau of Nur-Sultan city Administration, 010000 Nur-Sultan, Kazakhstan
6Department of Women and Children's Health, University of Padua, 35122 Padua, Italy
7Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, 21100 Varese, Italy
8Department of Medicine, School of Medicine, Nazarbayev University, 020000 Nur-Sultan, Kazakhstan
9Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
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Abstract  
Background: Abnormal uterine bleeding is a common sign which cover various conditions e/o pathologies. Different approaches are used to evaluate this condition. The aim of this study was to investigate the validity of Pipelle biopsy for endometrial sampling in Kazakhstani women with abnormal uterine bleeding. For this reason, we carried out a prospective study of 120 patients who underwent endometrial sampling due to abnormal uterine bleeding in a tertiary hospital setting in Kazakhstan. Methods: Statistics included descriptive analysis to evaluate the frequency of various endometrial conditions. The validity of Pipelle biopsy sampling was calculated by estimating sensitivity, specificity, accuracy, and positive and negative predictive values. For the Pipelle sampling validity assessment, we analyzed 120 samples, as 21 patients with insufficient samples were excluded. Results: Overall, concordance in histopathologic results was 92.93%. Pipelle sampling identified two cases of adenocarcinoma in our group. Moreover, endometrial hyperplasia was detected with 71.43% sensitivity, 98.82% specificity, PPV of 90.91% and NPV of 95.45%. However, the Pipelle reliability was low in cases of endometrial polyps. In conclusion, the Pipelle method was found to be valid for the diagnosis of endometrial hyperplasia and adenocarcinoma with high SN, SP, PPV and NPV. Conclusions: The Pipelle technique for evaluation of abnormal uterine bleeding in the Kazakhstani health care setting is a useful method with the highest efficacy in ruling out endometrial hyperplasia and diagnosing adenocarcinoma. If endometrial polyp was suspected under ultrasound scan in patients with abnormal uterine bleeding, physicians should consider other tools for endometrial sampling.
Key words:  Pipelle      Dilatation and curettage      Abnormal uterine bleeding      Postmenopausal bleeding      Endometrial hyperplasia     
Submitted:  02 February 2021      Revised:  22 March 2021      Accepted:  24 March 2021      Published:  15 June 2021     
Fund: 
110119FD4540, 2019-2021/Nazarbayev University
*Corresponding Author(s):  Giovanni Buzzaccarini     E-mail:  giovanni.buzzaccarini@gmail.com

Cite this article: 

Gulzhanat Aimagambetova, Aiym Kaiyrlykyzy, Gauri Bapayeva, Talshyn Ukybassova, Kamila Kenbayeva, Bakytkali Ibrayimov, Alla Lyasova, Giulio Bonaldo, Giovanni Buzzaccarini, Marco Noventa, Antonio Simone Laganà, Milan Terzic. Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 670-675.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.03.2510     OR     https://ceog.imrpress.com/EN/Y2021/V48/I3/670

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