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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (2): 312-316    DOI: 10.31083/j.ceog.2021.02.5507
Original Research Previous articles | Next articles
Oxidative stress status in severe OHSS patients who underwent long agonist protocol intracytoplasmic sperm injection cycles
R. Duraker1, E.S. Guvendag Guven2, S. Dilbaz1, A. Mentese3, S. Aydın4, S. Guven2, *()
1Department of Obstetrics and Gynecology, Etlik Womens' Health and Teaching Hospital, 06170 Ankara, Turkey
2Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
3Program of Medical Laboratory Techniques, Vocational School of Health Sciences, Karadeniz Technical University, 61080 Trabzon, Turkey
4Department of Histology and Embryology, Ankara University, Faculty of Medicine, 06590 Ankara, Turkey
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Abstract  
Purpose of investigation: Current infertility treatment strategies may result in ovarian hyperstimulation syndrome (OHSS), which can present with hemodynamic instability that involves hemoconcentration, hypoxia, and liver and renal dysfunction that may result from thrombosis. This study's purpose was to measure the serum biochemical oxidative stress markers in women with severe OHSS. Material and methods: For this prospective controlled study, serum levels of ischemia modified albumin (IMA), total antioxidant capacity (TAC), total oxidative capacity (TOS), oxidative stress capacity (OSI), and serum malondialdehyde (MDA) were measured in women with (n = 25) and without (n = 27) OHSS. Results: In our study, we observed significant differences between the two groups in terms of IMA, TAC, TOS, OSI, and MDA levels. High oxidative stress parameter levels in the OHSS group may indicate that OHSS is an oxidative stress condition. A bivariate correlation analysis revealed a significant correlation between serum TOS level, OSI ratio, and embryo or oocyte quality scores. In addition, there was a negative, non-significant tendency among OHSS patients regarding high IMA, OSI, TOS, and MDA levels and low oocyte and embryo scores. Pregnancy results were not affected in a statistically significantly manner. Conclusion: These results might indicate that oxidative stress status and oxygen radicals may negatively affect ART cycle outcomes.
Key words:  IMA      ICSI      Infertility      OHSS      Oxidative stress      Ovulation induction     
Submitted:  04 February 2020      Revised:  15 July 2020      Accepted:  31 July 2020      Published:  15 April 2021     
*Corresponding Author(s):  Suleyman Guven     E-mail:  drsuleymanguven@yahoo.com

Cite this article: 

R. Duraker, E.S. Guvendag Guven, S. Dilbaz, A. Mentese, S. Aydın, S. Guven. Oxidative stress status in severe OHSS patients who underwent long agonist protocol intracytoplasmic sperm injection cycles. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 312-316.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.02.5507     OR     https://ceog.imrpress.com/EN/Y2021/V48/I2/312

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