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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (2): 216-222    DOI: 10.31083/j.ceog.2021.02.2207
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The effect of oral vitamin E supplementation on infertile women: a systematic review and meta-analysis
Jia-Hui Wu1, 2, †, Dan-Ni Yang1, 2, †, Li-Juan Cao1, Jia-Qi Luo1, Wei-Ping Qian1, Wen-Min Ma3, Xi Xia1, *()
1Center for Reproductive Medicine, Peking University Shenzhen Hospital, Futian District, 518000 Shenzhen, Guangdong, China
2Shenzhen Maternal and Child Healthcare Hospital Affiliated to Southern Medical University, Futian District, 518000 Shenzhen, Guangdong, China
3Foshan Women and Children Hospital, 528000 Foshan, Guangdong, China
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Abstract  
This study was aimed to investigate the effect of vitamin E (Vit E) supplementation on endometrial thickness and pregnancy outcomes in infertile women. The literature was screened by two researchers and the data was extracted by searching published literature from 1999 to 2020 in the Cochrane library, PubMed, and Embase database. Seven clinical trials were included, with a total of 652 subjects. Here we found the mean endometrium was thicker in Vit E treatment group than that in the control group [SMD = 0.57, 95% CI (0.26, 0.87), P = 0.0002]. Subgroup analysis showed that no significant effect between administration of 400 IU (267 mg) or 100 mg Vit E per day. There was no significant difference between with or without Vit E on ongoing pregnancy rate [OR = 1.08, 95% CI (0.72, 1.62), P = 0.70]. The current evidence demonstrates that Vit E supplementation may increase endometrial thickness in women of reproductive age.
Key words:  Vitamin E supplementation      Endometrial thickness      Ongoing pregnancy      Systematic review     
Submitted:  01 July 2020      Revised:  11 September 2020      Accepted:  23 September 2020      Published:  15 April 2021     
*Corresponding Author(s):  Xi Xia     E-mail:  xixia1126@hotmail.com
About author:  These authors contributed equally.

Cite this article: 

Jia-Hui Wu, Dan-Ni Yang, Li-Juan Cao, Jia-Qi Luo, Wei-Ping Qian, Wen-Min Ma, Xi Xia. The effect of oral vitamin E supplementation on infertile women: a systematic review and meta-analysis. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 216-222.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.02.2207     OR     https://ceog.imrpress.com/EN/Y2021/V48/I2/216

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