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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (1): 105-109    DOI: 10.31083/j.ceog.2021.01.5417
Original Research Previous articles | Next articles
Effective doses 50% and 95% of subarachnoid injection of sufentanil with ropivacaine in lumbar anesthesia for cesarean section in severe preeclampsia
Jing Wang1, Min Zhou1, *(), Li Zhang1, Long-Xin Zhang1
1Department of Anaesthesia, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 350001 Fuzhou, P. R. China
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Abstract  
Objective: This study aimed to determine the ED50 and ED95 of 10 mg of 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia by the sequential method. Methods: A total of 47 patients with severe preeclampsia, who underwent cesarean section, were enrolled in the present study. The first patient was given a subarachnoid injection of 10 mg of isobaric 0.5% ropivacaine plus 2.5 μg of sufentanil. If the anesthetic effect was satisfactory, the dose of sufentanil used for the next patient was reduced by 0.5 μg. If the anesthetic effect was unsatisfactory, the dose of sufentanil used for the next patient was increased by 0.5 μg. Results: The ED50 of sufentanil was 1.830 μg, with a 95% CI ranging within 1.517–2.128 μg, while the ED95 of sufentanil was 2.852 μg with a 95% CI ranging within 2.429-4.338 μg. Conclusion: The ED50 and ED95 of 10 mg of isobaric 0.5% ropivacaine combined with different doses of sufentanil in lumbar anesthesia for cesarean sections in patients with severe preeclampsia were 1.830 μg and 2.852 μg, respectively.
Key words:  Ropivacaine      Sufentanil      Severe preeclampsia      Cesarean section      Dose-effect relationship     
Submitted:  22 March 2020      Revised:  15 July 2020      Accepted:  22 July 2020      Published:  15 February 2021     
*Corresponding Author(s):  Min Zhou     E-mail:  minzhou_123@163.com

Cite this article: 

Jing Wang, Min Zhou, Li Zhang, Long-Xin Zhang. Effective doses 50% and 95% of subarachnoid injection of sufentanil with ropivacaine in lumbar anesthesia for cesarean section in severe preeclampsia. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 105-109.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.01.5417     OR     https://ceog.imrpress.com/EN/Y2021/V48/I1/105

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