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Is visual inspection with acetic acid (VIA) a useful method of finding pre-invasive cervical cancer? |
Maliheh Arab1, *( ), Atefeh Moridi2, Ghazaleh Fazli3, Robabeh Ghodssi-Ghasemabadi4, Maryam Maktabi5, Samaneh Saraeian6, Mahdie Sanati7 |
1Gynecology-Oncology, Cancer Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran 2Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran 3Department of Developmental Biology, Science and Research University of Tehran, 1417466191 Tehran, Iran 4Department of Biostatistics, Tarbiat Modares University, 14117-13116 Tehran, Iran 5Obstetrics & Gynecology, Arak University of Medical Sciences, 38156879 Arak, Iran 6Obstetrician & Gynecologist, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran 7Developmental biology, Science and Research University of Tehran, 1417466191 Tehran, Iran |
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Abstract
Purpose of investigation: The prospects for effective cytological screening in the majority of developing countries are limited. This study evaluated visual inspection with acetic acid (VIA) for the diagnosis of CIN 2-3 in case findings. Materials and Methods: In this prospective study, 1437 asymptomatic women were screened using VIA followed by colposcopy-biopsy of all cases. The predictive efficacy of VIA was determined based on pathological confirmation of CIN 2-3 on colposcopy-directed biopsy. Results: In 388 (27%) out of 1437 cases, the VIA was positive. In 31 (2.1%) cases, CIN 2-3 was confirmed on cervical biopsy. The sensitivity, specificity and negative predictive value (NPV) of the VIA were 41.9%, 73.3%, and 98.2%, respectively. Conclusion: The present study confirmed the value of VIA for screening, with sensitivity of 41.9% and NPV of 98.2%. Future studies should determine the best place for VIA testing alongside other types of testing in screening algorithms.
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Submitted: 04 July 2020
Revised: 15 October 2020
Accepted: 16 November 2020
Published: 15 February 2021
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*Corresponding Author(s):
Maliheh Arab
E-mail: drmarab@sbmu.ac.ir
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