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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (1): 179-184    DOI: 10.31083/j.ceog.2021.01.2131
Original Research Previous articles | Next articles
Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study
Mahvash Zargar1, *(), Razieh Pazhouhanfar1, Mahin Najafian1, Parastoo Moradi Choghakabodi2
1Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of medical sciences, 61357-15794 Ahvaz, Iran
2Ahvaz Jundishapur University of Medical Sciences; Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 61357-15794 Ahvaz, Iran
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Abstract  
Purpose: Evaluation of the effect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, including patients who received an intrauterine infusion of PRP (n: 40) and controls (n: 40). Before PRP therapy, standard hormone replacement therapy was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrium, PRP was injected into all patients' endometrium whether they had an appropriate endometrial thickness or not. Then, the embryo transferring was done through IVF. Eventually, the consequences of fertility, embryo implantation, and pregnancy were evaluated. Data analysis was performed using SPSS version 22. Results: The rate of successful IVF [6 (15%)], pregnancy rate [5 (12.5%)], and live birth [5 (12.5%)] were relatively higher in patients undergoing PRP therapy compared with controls [2 (5%), 1 (2.5%) and 0, respectively]. However, their statistical difference was not significant between the two groups (P > 0.05). Conclusion: Our findings suggest that endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates.
Key words:  Platelet-rich plasma      Platelet-derived growth factor      In vitro fertilization      Pregnancy rate      Live birth      Women     
Submitted:  07 May 2020      Revised:  09 November 2020      Accepted:  13 November 2020      Published:  15 February 2021     
Fund: Ahvaz Jundishapur University of Medical Sciences
*Corresponding Author(s):  Mahvash Zargar     E-mail:  Zargar_m@ajums.ac.ir

Cite this article: 

Mahvash Zargar, Razieh Pazhouhanfar, Mahin Najafian, Parastoo Moradi Choghakabodi. Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 179-184.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.01.2131     OR     https://ceog.imrpress.com/EN/Y2021/V48/I1/179

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