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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (6): 875-881    DOI: 10.31083/j.ceog.2020.06.5454
Original Research Previous articles | Next articles
The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels
I. Thanaboonyawat1, P. Chera-aree1, *(), S. Petyim1, R. Choavaratana1, P. Laokirkkiat1
1Infertility and Reproductive Biology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
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Abstract  
Objective: The effects of daily topical application of testosterone gel on semen characteristics in infertile men with oligozoospermia and hypogonadism were assessed. Methods: Sixteen infertile men were included in this prospective study. A daily morning application of 25 mg transdermal testosterone T gel was used for 3 months. Semen parameters, serum follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol E and T levels, and seminal plasma E and T levels were measured before treatment and once monthly for three months during the therapy. Results: The baseline median sperm concentration was 5.5 × 106/mL. Median sperm concentrations at the first, second and third months were 9 × 106, 8 × 106, and 4 × 106/mL, respectively. The sperm concentrations at the first and second months after starting therapy significantly (p < 0.001) increased compared with the baseline. However, sperm volume, pH, motility, viability and morphology were similar to baseline. Serum T significantly (p < 0.001) increased, while serum FSH significantly (p < 0.001) decreased from baseline. Seminal T and T/E ratios were raised significantly (p = 0.008 and p = 0.004, respectively) after gel application, whereas the seminal E level was not affected. Conclusions: Daily 25 mg T gel applications for oligospermic infertile men with hypogonadism increased the sperm concentration at the first and second months and raised the serum T level to the normal adult male range. Nevertheless, the sperm concentration had a decreasing trend after the third month.
Key words:  Testosterone gel      Oligozoospermia      Hypogonadism      Sperm concentration      Seminal testosterone/estradiol ratio      Male infertility     
Submitted:  19 November 2019      Accepted:  18 May 2020      Published:  15 December 2020     
Fund: 
R015932020/ supported by a Siriraj Grant for Research Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
*Corresponding Author(s):  PATTRAPORN CHERA-AREE     E-mail:  Pattraporn.che@mahidol.ac.th

Cite this article: 

I. Thanaboonyawat, P. Chera-aree, S. Petyim, R. Choavaratana, P. Laokirkkiat. The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 875-881.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.06.5454     OR     https://ceog.imrpress.com/EN/Y2020/V47/I6/875

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