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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (6): 862-866    DOI: 10.31083/j.ceog.2020.06.5425
Original Research Previous articles | Next articles
Maternal serum levels of SCUBE1 in missed abortion
E. Destegül1, *(), S. Gençdal2, İ. Sarı3, H. Akkaya4, N. Gençdal2, B. Çakmak1
1Nigde Omer Halisdemir University Medical Faculty Education and Research Hospital Department of Obstetrics and Gynecology, Nigde, Turkey
2İzmir Katip Celebi University, Atatürk Education and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Turkey
3Nigde Omer Halisdemir University Medical Faculty Department of Biochemistry, Nigde, Turkey
4Ankara City Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey
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Abstract  
Purpose of Investigation: To investigate the alterations of SCUBE1 levels in patients with missed abortion. Materials and Methods: Patients with missed abortion (n = 40) and age and gestational age-matched with normal early pregnancy cases (n = 40) were recruited for the study. All the patients’ ultrasound examinations were performed by single physician to assess the variability of conception. And to evaluate the SCUBE1 levels, venous blood samples were collected and measured with specific enzyme-linked immunosorbent assays. Results: SCUBE1 levels were found lower at missed group than control group (p < 0.001) while other hematologic parameters were similar in both groups. Conclusion: Low maternal blood levels of the SCUBE1 may be related with missed abortion by causing alterations in placental angiogenesis.
Key words:  Missed abortion      SCUBE1      Pregnancy loss      Signal peptide-CUB epidermal growth factor domain containing protein     
Submitted:  11 December 2019      Accepted:  30 April 2020      Published:  15 December 2020     
*Corresponding Author(s):  EMRE DESTEGÜL     E-mail:  destegulemre@hotmail.com

Cite this article: 

E. Destegül, S. Gençdal, İ. Sarı, H. Akkaya, B. Çakmak, N. Gençdal. Maternal serum levels of SCUBE1 in missed abortion. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 862-866.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.06.5425     OR     https://ceog.imrpress.com/EN/Y2020/V47/I6/862

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