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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (5): 714-722    DOI: 10.31083/j.ceog.2020.05.5360
Original Research Previous articles | Next articles
Gestational age estimation from ultrasound fetal biometrics in China
J.F. Sun1, L.J. Zhang1, L.Q. Cui2, X.D. Luo3, G.H. He4, X.J. Dong3, L. He2, J.H. Zhang5, J.H. Sun6, G. Chen1, Y. Lv7, L.Y. Liu1, *()
1Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing, P.R. China
2Department of ultrasound, University-Town Hospital of Chongqing Medical University, Chongqing, P.R. China
3Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
4College of Mathematics and Statistics, Chongqing University, Chongqing, P.R. China
5Health Management Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
6Department of Obstetrics and Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
7Chongqing Pepper Technology Co., Ltd. Chongqing, P.R. China
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Abstract  
Objective: To establish a new gestational age estimation equation in China and compare them with commonly used equations of 2017 and 1984. Methods: A prospective cross-sectional study was performed in 3208 fetuses between 15 and 40 weeks of gestation. The following biometric variables were recorded: biparietal diameter, head circumference, abdominal circumference, and femur length. Women with a certain gestational age were confirmed by the last menstrual period with a regular cycle of 26–32 days. Subsequently, a mixed regression model was used for regression analysis for the estimation equation of gestational age. Additionally, validation set was used to verify the accuracy of the equation. Estimation error was defined as the mean square deviation between the estimation equation and observed gestational age and its accuracy was compared with that analyzed by Hadlock and National Institute of Child Health and Human Development (NICHD) equations. Results: The gestational age estimation errors of the new equation are within 9.62 days from 15 to 20 weeks, 7.90 days from 21 to 25 weeks, 11.76 days from 26 to 30 weeks, 9.35 days from 31 to 35 weeks, and within 11.30 days from 36 to 40 weeks of gestation. Compared to the results evaluated by the Hadlock and NICHD equations, the estimation of the new equation has significantly improved gestational age determination in the second and third trimesters. Conclusions: The estimation results of the new equation is superior to those of the Hadlock and NICHD equations and provides more accurate results for gestational age estimation with ultrasonic examination.
Key words:  Biparietal diameter      Head circumference      Abdominal circumference      Femur length     
Submitted:  30 August 2019      Accepted:  18 March 2020      Published:  15 October 2020     
Fund: 
11974066/National Natural Science Foundation of China
11674043/National Natural Science Foundation of China
cstc2019jcyj-msxmX0477/Natural Science Foundation of Chongqing
cstc2018jcyjA3679/Natural Science Foundation of Chongqing
2019CDYGYB007/Fundamental Research Funds for the Central Universities
*Corresponding Author(s):  LIYU LIU     E-mail:  lyliu@cqu.edu.cn

Cite this article: 

J.F. Sun, L.J. Zhang, L.Q. Cui, X.D. Luo, G.H. He, X.J. Dong, L. He, J.H. Zhang, J.H. Sun, G. Chen, Y. Lv, L.Y. Liu. Gestational age estimation from ultrasound fetal biometrics in China. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 714-722.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.05.5360     OR     https://ceog.imrpress.com/EN/Y2020/V47/I5/714

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