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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (4): 524-529    DOI: 10.31083/j.ceog.2020.04.5417
Original Research Previous articles | Next articles
Effect of aminophylline on restoration of spontaneous respiration and recovery profiles during anesthesia without using muscle relaxants in patients undergoing brief gynecological procedure
Y.S. Jeon1, E.H. Jun1, J.H. Kim1, S.T. Choi1, J.H. In1, *()
1Department of Anesthesiology and Pain Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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Abstract  

Purpose of Investigation: The purpose was to evaluate the effects of aminophylline on returning of spontaneous respiration and recovery profiles during propofol-fentanyl-sevoflurane anesthesia without muscle relaxants in patients undergoing day care gynecological surgery. Materials and Methods: Sixty-six patients were enrolled. Either aminophylline 3 mg/kg (group A) or saline (group C) was administered to each patient. Tidal volume (Vt), respiratory rate (RR), and end tidal carbon dioxide (ETCO2), apneic time, recovery time, discharge time and modified observer’s assessment of alertness/sedation scale (MOAA/S) were evaluated. Results: Apneic time and recovery time were significantly shorter in Group A than in Group C (P < 0.01). MOAA/S, tidal volume (P = 0.02) and ETCO2 (P = 0.03) were significantly improved in Group A compared with Group C. Conclusion: Aminophylline effectively reduced apneic and recovery time, thereby improving respiratory and recovery profiles during anesthesia with propofol, fentanyl, and sevoflurane in brief day care surgeries.

Key words:  Aminophylline      Hypercapnia      Anesthesia recovery period     
Submitted:  19 November 2019      Accepted:  11 March 2020      Published:  15 August 2020     
*Corresponding Author(s):  J.H. In     E-mail:  ijangh@hanmail.net

Cite this article: 

Y.S. Jeon, E.H. Jun, J.H. Kim, S.T. Choi, J.H. In. Effect of aminophylline on restoration of spontaneous respiration and recovery profiles during anesthesia without using muscle relaxants in patients undergoing brief gynecological procedure. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 524-529.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.04.5417     OR     https://ceog.imrpress.com/EN/Y2020/V47/I4/524

Table 1  — Modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S).
Score
Agitated 6
Responds readily to name spoken in normal tone (Alert) 5
Lethargic response to name spoken in normal tone 4
Responds only after name is called loudly and/or repeatedly 3
Responds only after mild prodding or shaking 2
Does not respond to mild prodding or shaking 1
Does not respond to deep stimulus 0
Table 2  — Patient characteristics.
Group A (n = 33) Group C (n = 33) P
Age (yrs) 46.5 ± 11.3 47.6 ± 12.5 0.71
Body weight (kg) 57.4 ± 9.2 56.8 ± 8.4 0.81
Height (cm) 160.6 ± 4.7 158.8 ± 4.8 0.13
Duration of anesthesia (min) 26.9 ± 10.5 23.4 ± 15.9 0.29
Table 3  — Recovery and respiratory profiles.
Group A
(n = 33)
Group C
(n = 33)
P
Recovery
Recovery time (min) 6.2 ± 2.8 8.2 ± 3.0 < 0.01
Discharge time (min) 32.2 ± 4.8 33. ± 5.3 0.23
MOAA/S on arrival at PACU 0.6 ± 0.7 0.4 ± 0.6 0.38
MOAA/S at 15 min 4.0 ± 0.7 3.4 ± 0.7 0.02
MOAA/S at 30 min 4.8 ± 0.6 4.3 ± 0.5 0.01
Respiratory
Apneic time (sec) 68.8 ± 25.2 93.9 ± 30.0 < 0.01
TSevo2.5 (sec) 104.2 ± 40.0 96.5 ± 39.1 0. 43
Figure 1.  — Perioperative changes of respiratory variables. (A) Tidal volume (B) Respiratory rate (C) End tidal carbon dioxide (ETCO2). Group A, aminophylline group; Group C, control group. T2, 5 minutes after induction of anesthesia; T3, 10 minutes after induction of anesthesia; T4, 15 minutes after induction of anesthesia; T5, 20 minutes after induction of anesthesia. *P < 0.05 compared to Group C. Overall changes over time of tidal volumes and ETCO2 were significantly higher in Group A compared with Group C, while there was no significant difference in respiratory rate between the groups.

Table 4  — Perioperative changes of hemodynamic variables.
Heart rate (bpm) Mean arterial blood pressure (mmHg)
Group A
(n = 33)
Group C
(n = 33)
Group A
(n = 33)
Group C
(n = 33)
T1 64.9 ± 7.4 61.8 ± 7.0 80.7 ± 14.5 80.1 ± 13.9
T2 71.3 ± 9.5 67.2 ± 9.6 91.3 ± 16.2 86.6 ± 12.0
T3 65.2 ± 8.8 64.5 ± 8.5 79.8 ± 13.2 80.7 ± 13.5
T4 64.3 ± 8.1 62.6 ± 6.1 80.0 ± 12.2 80.6 ± 13.6
T5 65.5 ± 8.2 65.1 ± 6.2 77.2 ± 11.3 80.9 ± 17.2
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