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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (3): 396-400    DOI: 10.31083/j.ceog.2020.03.5302
Original Research Previous articles | Next articles
Acupuncture combined with Chinese and western medicine in the treatment of polycystic ovary syndrome
Xiao-Tao Huang1, *(), Shao-Rong Liang1, Lu Wang1
1Department of Integrated Traditional Chinese and Western Medicine, Hubei Provincial Maternal and Child Health Hospital, Wuhan 430070, P.R. China
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Abstract  

The present study aimed to evaluate the clinical effect of acupuncture combined with western medicine and Chinese medicine to tonify the kidney, promote blood circulation, and eliminate sputum in the treatment of polycystic ovary syndrome (PCOS). The 156 patients with PCOS who met the diagnostic criteria were randomly divided into the western medicine group who received Diane-35 (n = 40), the Chinese and western medicine group who received Diane-35 plus Chinese medicine to tonify the kidney, promote blood circulation, and eliminate sputum (n = 60), and the acupuncture and medicine group who received Chinese and western medicine plus acupuncture (n = 56). The groups received continuous treatment for three menstrual cycles. The pre- and post-treatment levels of serum testosterone (T) and fasting insulin (FINS), luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio, and ovulation rate were compared within the three groups. Compared with before treatment, all three groups showed decreases in the serum T and FINS levels and LH/FSH ratio (all P < 0.05). Moreover, the post-treatment decreases in serum T and FINS levels, LH/FSH ratio, and ovulation rate were superior in the acupuncture and medicine group compared with the western medicine group (P < 0.05) and Chinese and western medicine group (P < 0.05). The concomitant use of acupuncture, Diane-35, and Chinese medicine to tonify the kidney, promote blood circulation, and eliminate sputum is effective in treating PCOS.

Key words:  Polycystic ovary syndrome      Acupuncture      Chinese medicine      Western medicine      Treatment efficacy     
Submitted:  23 June 2019      Accepted:  04 September 2020      Published:  15 June 2020     
*Corresponding Author(s):  Xiao-Tao Huang     E-mail:  huang68xt@sina.com

Cite this article: 

Xiao-Tao Huang, Shao-Rong Liang, Lu Wang. Acupuncture combined with Chinese and western medicine in the treatment of polycystic ovary syndrome. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 396-400.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.03.5302     OR     https://ceog.imrpress.com/EN/Y2020/V47/I3/396

Table 1  — Comparison of clinical efficacy in the three groups after treatment (number of cases, %)
Group Cure Effective Invalid Effective rate
Acupuncture and medicine (56) 18(32.1%) 35(62.5%) 3(5.4%) 94.6%#
Chinese and western medicine (60) 13(21.7%) 41(68.3%) 6(10.0%) 90.0%*
Western medicine (40) 5(12.5%) 25(62.5%) 10(25.0%) 75.0%
Table 2  — Changes in T and FINS levels, LH/FSH ratio and ovulation rate among the three groups before and after treatment (mean ± SD)
Group T (ng/mL) LH/FSH (mIU/mL) FINS (mIU/L) Ovulation rate (%)
Acupuncture and medicine group
Before treatment 0.85 ± 0.37 4.02 ± 3.01 9.04 ± 3.25 0
After treatment 0.22 ± 1.74* 0.52 ± 3.47* 4.97 ± 3.44* 82.40*
Chinese and western medicine group
Before treatment 0.89 ± 0.36 3.87 ± 4.17 8.52 ± 3.29 0
After treatment 0.41 ± 1.28*# 1.34 ± 0.92*# 5.16 ± 3.36*# 60.5*#
Western medicine group
Before treatment 0.89 ± 0.28 3.47 ± 2.33 8.47 ± 3.03 0
After treatment 0.67 ± 3.33*# 2.28 ± 1.60*# 6.29 ± 3.82 *# 17.25*#
[1] Cao Z.Y.: “Chinese obstetrics and gynecology (clinical edition)”. Beijing: People's Medical Publishing House, 2010.
[2] Lang J.H.: “National continuing medical program education gynecology section”. Beijing: Electronic Audiovisual Publishing House of Chinese Medicine, 2007.
[3] Yu C.X., Li Y.X.: “Practical Gynecologic Endocrinology, 2nd edition”. Shanghai: Fudan University Press, 2004.
[4] Le J.: “Obstetrics and Gynecology. 7th edition”. Beijing: People's Health Publishing House, 2010.
[5] Yang DZ.: “Selection and application of gynecological endocrine diseases examination items”. Beijing: People's Medical Publishing House, 2011.
[6] Zheng XY.: “Clinical research guidelines for new Chinese medicines”. Beijing: China Medical Science Press, 2002.
[7] Cassar S., Misso M.L., Hopkins W.G., Shaw C.S., Teede H.J., Stepto N.K.: “Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies”. Hum Reprod. 2016, 31(11), 2619-2631.
doi: 10.1093/humrep/dew243 pmid: 27907900
[8] Li F.Q., Yin R.T., Xie D., Tong L.X.: “Progress in Prevention and treatment of polycystic ovarian syndrome”. Xiandai Yufang Yixue, 2014, 41(17), 3130-3132. (In Chinese)
[9] Hao C.Y.: “Impact of Diane-35 and Metformin on sex hormone level and insulin resistance in infertile patients with polycystic ovary syndrome”. Zhongguo Yiyao Daobao, 2016, 13(9), 128-130. (In Chinese)
[10] Ma J.: “Treatment of obese polycystic ovarian syndrome by tonifying kidney and eliminating phlegm, a report of 30 case”. Shandong Zhongyi Zazhi, 2007, 26(8), 537-538. (In Chinese)
[11] Shi G.L., Yue Y.H., Zhang C.Y.: “Effect of Yiqi Huoxue decoction on serum hormone secretion in patients with polycystic ovarian syndrome”. Shaanxi Zhongyi, 2017, 38(8), 1078-1079. (In Chinese)
[12] Agrawal K., Gainder S., Dhaliwal L.K., Suri V.: “Ovulation induction using clomiphene citrate using stair - step regimen versus traditional regimen in polycystic ovary syndrome women - a randomized control trial”. J Hum Reprod Sci. 2017, 10(4), 261-264.
doi: 10.4103/jhrs.JHRS_15_17 pmid: 29430152
[13] Czeczuga-Semeniuk E., Galar M., Jarząek K., Kozłwski P., Sarosiek N.A., Wołzyński S.: “The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women”. Adv Med Sci., 2018, 63(2), 242-248.
doi: 10.1016/j.advms.2018.01.002 pmid: 29428584
[14] Yu L.Q., Xie J., Zhang F.Q., Shi Y., Cao L.Y.: “Clinical study on acupuncture and moxibustion therapy for polycystic ovary syndrome (PCOS) with kidney deficiency and phlegm-dampness type. Zhenjiu Linchuang Zazhi, 2016, 32(2), 10-15. (In Chinese)
[15] Yang D.H., Zhao M., Tan J.H.: “Effect of polycystic ovary syndrome treated with the periodic therapy of acupuncture”. Zhongguo Zhenjiu, 2017, 37(8), 825. (In Chinese)
[16] Ma X.P., Tan L.Y., Yang Y., Wu H.G., Jiang B., Liu H.R., Yang L.: “Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome”. World J Gastroenterol. 2009, 15(41), 5211-7.
doi: 10.3748/wjg.15.5211 pmid: 19891022
[17] Stener-Victorin E., Lundeberg T., Cajander S., Aloe L., Manni L., Waldenströ U., Janson P.O.: “Steroid-induced polycystic ovaries in rats, effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system”. Reprod Biol Endocrinol. 2003, 1, 33.
doi: 10.1186/1477-7827-1-33 pmid: 12725645
[1] J. Dun, X. Wang, J. Yang, J. Xu. Clinical practice guidelines on polycystic ovary syndrome: a systematic review and comparative meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 465-471.
[2] A. M. Maysara, A. T. Nassar, H. K. Jubran. The effect of correction of serum level of vitamin D on hyperandrogenism in women with polycystic ovary syndrome and hypovitaminosis D[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 272-276.
[3] H.M.G. Youssef, E.S. Marei, L.A. Rashed. Long non-coding RNA steroid receptor activator in polycystic ovary syndrome: possible association with metabolic syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 757-762.
[4] S.M.S. Fernandes, J.C.L. Ribalta, N.M.G. Speck, Y. Yamamura. Treatment of uterine cervical ectopy with acupuncture and analysis of risk factors in the metaplastic process[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 601-605.
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[6] Hui-lan Wang, Xia Xu, Zhi-qun Zheng. The expression of Nuclear Factor-κB in a rat model of polycystic ovary syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 276-279.
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