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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (3): 424-426    DOI: 10.31083/j.ceog.2020.03.5215
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Recurrent hydatidiform mole: when to stop?
E. Ozbasli1, *(), O. Takmaz1, H. Gurkan2, Y. Alanay1, M. Gungor1, F.S. Dede1
1Department of Obstetrics and Gynecology, Acibadem University School of Medicine, Istanbul, Turkey
2Diagnostics Center for Genetic Diseases, University of Trakya, Trakya Medical Faculty, Edirne, Turkey
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Abstract  

Recurrent hydatidiform mole (RHM) is defined as two or more repeated molar pregnancies in the same patient. Familial recurrent hydatidiform mole (FRHM) is a rare condition in which the patient has relatives with the same condition and mutations. Maternal mutations in the NLRP7 gene are mostly observed in RHM. The authors report a patient from Turkey with a history of seven molar pregnancies who had an aunt with similar obstetric history and NLRP7 mutations.
Key words:  Familial hydatidiform mole      NLRP7      Ovum donation      Genomic imprinting     
Submitted:  04 March 2019      Accepted:  04 June 2019      Published:  15 June 2020     
*Corresponding Author(s):  ESRA OZBASLI     E-mail:  esraizmit@gmail.com
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Cite this article: 

E. Ozbasli, O. Takmaz, H. Gurkan, Y. Alanay, M. Gungor, F.S. Dede. Recurrent hydatidiform mole: when to stop?. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 424-426.

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https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.03.5215     OR     https://ceog.imrpress.com/EN/Y2020/V47/I3/424

Table 1  — PCR conditions of primers used in NLRP7 mutation analysis
Exon Primer sequences (5’-3’) T (°C) Size (bp)
1 Forward AGCCCACTGAAGCCCAATTACA 58.7 348
Reverse AGCATCCTCGCACCAACCATTA
2 Forward CTTGGCACACAGGAAACTGTGGTT 60 392
Reverse TACCCATCATCTCAGCCTTTGCCA
3 Forward ACCATGCCTGGCTGACACTTTA 58 221
Reverse TGCACCTTGCATGCTCTCAA
4 Forward 4-1 CCTGGCCCTCATTTCTGGTA 60 371
Reverse 4-1 TTGCAGCTGAGGTAGAACGC
Forward 4-2 CTGGACAGACTGCAACCTCAGC 60 427
Reverse 4-2 GTGTCTCAGGAAATAGGCCCTCC
Forward 4-3 TTCCAAGCATCCTAGCCCAA 56 406
Reverse 4-3 AGAGTCGTGCACACAATCCA
Forward 4-4 AGCAGCCGATCTACGTAAGGGTG 60 417
Reverse 4-4 TGTCTCCGTCCAGGAACAGACG
Forward 4-5 TCCAAAGGCTGCTACTCCTT 56 236
Reverse 4-5 AAAGTGGCCTCCAACTCCTT
Forward 4-6 TCGCTAACGAGAAGAGAGCCAA 58 432
Reverse 4-6 TGACAGTAAGCGACAGGGCAAA
5 Forward ATGTGGTTTGCAGATGCCCA 57.4 313
Reverse AGTCATCGTTCAGGGTCTTCCT
6 Forward ACCCGGCCAAGAACTTCTAA 56 402
Reverse AATACATTCCCTGTCTGGGACG
7 Forward ACGCCTTTGCATTCCAGACT 58 367
Reverse TGGCGCAGTAAGTCAGGTGTTA
8 Forward AGCAGGTTGGAGTTGTGGAA 56 360
Reverse TGGCCTCTGCCTGTTCTTTA
9 Forward TAACTGCTTCACAGGGCGTT 56 353
Reverse ATCAAGCCTGGAAGACCGAA
10 Forward 10-1 ACACGCTTGAGCCACTACCT 60 205
Reverse 10-1 TTGTCTTAGAACCCCAAAGAGC
Forward 10-2 GCTTGAAACTCTGGACCTGG 60 642
Reverse 10-2 GGGCAACAGTGAGACTCCAT
11 Forward 11-1 TTCAGGCATCCTGGGTAGTT 55.5 278
Reverse 11-1 ACCCTCTGACCTGCATTCAT
Forward 11-2 TTGATTGCAATGCTTCCGGG 56 462
Reverse 11-2 TCACATAGATGCACCTGGCA
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