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Influence of cytokines on the postoperative period |
D. Jovanovic1, *( ), D. R. Milovanovic2, I. Jovanovic3, M. Folic2, V. Jakovljevic4, 5 |
1Department of Anesthesiology and Reanimatology, Clinical Centre "Kragujevac", Kragujevac, Serbia 2Department of Clinical Pharmacology, Clinical Centre "Kragujevac", Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia 3Department of Immunology, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia 4Department of Physiology, Faculty of Medical Sciences University of Kragujevac, Kragujevac, Serbia 5University IM Sechenov, Department of Human Pathology, 1st MOSCOW State Medical, Moscow Russian Federation, Serbia |
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Abstract
Purpose of Investigation: The relationships between postoperative recovery and changes of circulating levels of pro- and anti-inflammatory cytokines. Materials and Methods: The study included prospectively a cohort of 51 females who underwent abdominal hysterectomy for benign diseases. Recovery was assessed with Quality of Recovery 40 (QoR-40) questionnaire and concentrations of four cytokines during the 72-hours period were measured using human sensitive enzyme-linked immunosorbent assay (ELISA) kits. Results: Total QoR-40 score significantly declined on the first and the second postoperative days and then returned to baseline (p < 0.001). Interleukin-17 serum levels had no significant trend (p = 0.072). Statistically significant patterns of concentration changes of interferon gamma (p = 0.010), interleukin-10 (p < 0.001), and transforming growth factor (p = 0.016) were found. There were no significant correlations between QoR-40 scores and concentrations of any cytokine, at prespecified study power for moderate relationships at least. Conclusion: Recovery after abdominal hysterectomy was rapid and complete and it was unrelated to serum concentration profiles of examined cytokines.
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Published: 15 February 2020
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*Corresponding Author(s):
D. Jovanovic
E-mail: danijeladrjovanovic@gmail.com
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