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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 812-814    DOI: 10.12891/ceog5179.2019
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The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence
J.H. Check1, 2, *(), D. Check2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA
2Cooper Institute for Reproductive Hormonal Disorders, P.C. Mt. Laurel, NJ, USA
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Abstract  

Purpose: To evaluate the efficacy of treatment with dextroamphetamine sulfate for severe idiopathic urgency urinary incontinence refractory to treatment with the selective beta 3 adrenergic agonist, mirabegron. Materials and Methods: Dextroamphetamine sulfate extended release capsule was started at 9.4 mg and increased to 15.7 mg in a woman with two years of severe urgency urinary incontinence. Results: The urgency urinary incontinence completely resolved, as did the fibromyalgia, headaches, and chronic fatigue syndrome. The symptoms have remained eradicated for over one year while treatment continues. Conclusions: Idiopathic urgency urinary incontinence (neurogenic bladder) has been found to be another manifestation of the increased cellular permeability syndrome. Similar to the other chronic disorder associated with the increased cellular permeability syndrome, idiopathic urgency urinary incontinence responds well to dextroamphetamine sulfate treatment despite failure to respond to standard therapy.

Key words:  Idiopathic urgency urinary incontinence      Neurogenic bladder      Dextroamphetamine sulfate      Increased cellular permeability syndrome      Dopamine     
Published:  10 October 2019     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, D. Check. The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 812-814.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog5179.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/812

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[2] H. Kwon, J.E. Shin, H. Kim. A novel treatment of severe dysmenorrhea due to adenomyosis: a case series of 3 infertile patients treated with dopamine agonist and in vitro fertilization-embryo transfer resulting in successful pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 637-640.
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