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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (6): 897-902    DOI: 10.12891/ceog4801.2019
Original Research Previous articles | Next articles
Hereditary thrombophilia in the puerperium: a retrospective review of 11 cases complicated by cerebral venous thrombosis
C. Ilea1, 2, I. Anghelache Lupascu1, 2, I. Stoian2, P. Vicoveanu1, 3, *(), D. Socolov1, 2
1Department of Obstetrics and Gynecology, Faculty of Medicine, "Gr.T.Popa" University of Medicine and Pharmacy, Iasi, Romania
2“Cuza Vodă” University Hospital, Iasi, Romania
3“Saint John” Emergency Hospital, Suceava, Romania
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Abstract  

Purpose of Investigation: The purpose of this study was to conduct a multidisciplinary analysis of a 11 cases of cerebral venous thrombosis in the puerperium associated with hereditary thrombophilia. Materials and Methods: The medical records of patients with ereditary thrombophilia and cerebral venous thrombosis in the puerperium were reviewed retrospectively. Clinical suspicion of cerebral venous thrombosis had been confirmed by CT or MRI. Results: Only in 11 cases the authors found the association between hereditary thrombophilia and cerebral thrombosis. The evaluation of the thrombophilic profile revealed that MTHFR C677T in combination with Factor V Leiden G1691A and Prothrombin G20210A were the commonest gene defects among cases studied. Conclusion: Hereditary thrombophilia may increase the risk of cerebral venous thrombosis in the puerperium.

Key words:  Thrombophilia      Pregnancy      Cerebral thrombosis      CT      MRI     
Published:  10 December 2019     
*Corresponding Author(s):  P. VICOVEANU     E-mail:  petronelapintilie@yahoo.com

Cite this article: 

C. Ilea, I. Anghelache Lupascu, I. Stoian, P. Vicoveanu, D. Socolov. Hereditary thrombophilia in the puerperium: a retrospective review of 11 cases complicated by cerebral venous thrombosis. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 897-902.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4801.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I6/897

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