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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (3): 423-426    DOI: 10.12891/ceog4794.2019
Original Research Previous articles | Next articles
Cytogenetic analysis of miscarriage materials of couples with recurrent pregnancy loss in a tertiary center
H. Akin1, E. Karaca1, I. Hortu2, *(), H. Bolat1, Z. Cengisiz1, M. Kazandi2, B. Durmaz1, A. Aykut1, A. Durmaz1, O. Cogulu1
1Department of Medical Genetics, Ege University School of Medicine, Izmir, Turkey
2Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey
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Abstract  

A pregnancy loss (miscarriage) is defined as the spontaneous demise of a pregnancy before the fetus reaches viability. The term therefore includes all pregnancy losses from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss (RPL) is defined as two or more losses of the pregnancy. There are many proposed reasons; however in a prominent portion of cases, the reason remains unclear. Chromosomal abnormalities have an important place in recurrent pregnancy loss. Numerical and structural abnormalities constitute a significant cause. The purpose of this study was to assess the chromosomal abnormality of 490 chorionic villus samples of the couples who experienced RPL and to provide data for both clinicians and genetic counsellors.

Key words:  Recurrent pregnancy loss      Abortion      Cytogenetic abnormalities     
Published:  10 June 2019     
*Corresponding Author(s):  I. HORTU     E-mail:  ismethortu@yahoo.com

Cite this article: 

H. Akin, E. Karaca, I. Hortu, H. Bolat, Z. Cengisiz, M. Kazandi, B. Durmaz, A. Aykut, A. Durmaz, O. Cogulu. Cytogenetic analysis of miscarriage materials of couples with recurrent pregnancy loss in a tertiary center. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 423-426.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4794.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I3/423

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[2] J. Wang, S.W. Chen, X.Y. Qin, X.Z. Zheng, P. Wang, X.Y. Cai. Clinical application of short tandem repeat polymorphism analysis in the differential diagnosis of early hydatidiform mole and hydropic abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 490-495.
[3] E.H. Comert, H. Sal, E.S. Guvendag Guven, S. Guven. Pulmonary lymphangioleiomyomatosis as an uncommon cause of recurrent early pregnancy loss[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 831-832.
[4] L. Wu, M. Zheng, M. Bao, X. Tong, Y. Liu, H. Han. Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 626-629.
[5] Y. Gao, P. Wang, T. Zou, Z. Zhang, W. Liang. Increased Th17 and reduced Treg cells in patients with unexplained recurrent spontaneous abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 458-460.
[6] S. Yaman, N. Hançerlioğulları, A. Tokmak, S. Ayhan, M. Alış ık, Ö. Erel. Impaired serum thiol/disulphide homeostasis may be another explanation for the pathogenesis of missed abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 50-54.
[7] Xiaomin Kanga, Tongfei Wanga, Shijin Xiaoa, Aimin Zhaoa. A successful pregnancy following 11 miscarriages in an unexplained recurrent pregnancy loss patient with thrombophilia: a case report and literature review[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 935-938.
[8] Hai-jing Xu, Zhi-lan Liu, Xiao-min Kang, Li-ying He, Tong-fei Wang, Chao Chen, Ai-min Zhao. Subchorionic hematoma complicated by different antenatal complications: a case report of four patients with spontaneous abortion and literature review[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 942-945.
[9] Hailong Zhai, Zhongjuan Li, Haibo Zhu, Jianping Deng, Hongliang Wang. Abnormal reproductive history associated with aberrant chromosomal structure: two cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 775-777.
[10] A.A. Rouzi, N. AlSinani, N. AlMansouri, N. Alsahly. Intra-cervical misoprostol for the treatment of second-trimester fetal demise[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 344-346.
[11] Liyan Zhang, Xiufen Zhao, Xiao Zhou. A study of the relationship between thyroid autoantibodies and early missed abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 396-399.
[12] Yaqin Mu, Jian Wang, Runhua Liu, Caixia Qi, Guoping Xi, Fuxi Zhao, Zhuangyan Zhu. Expression of heparanase in the spontaneously aborted human chorionic villus[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 174-177.
[13] Guiling Wang, Aifang Jiang, Chun'e Ren. The relationship between qh+ and recurrent spontaneous abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(1): 102-104.
[14] H. Alptekin, N. Alptekin, R. Selimoğlu, T. Cengiz, S. Barış. Inherited thrombophilia and thromboprophylaxis: a retrospective analysis of pregnancy outcomes in 106 patients[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 749-754.
[15] F. Eskicioğlu, K. Özbilgin, S. Taşkend, T. Önal, T. Gökmen. The role of angiogenic factors in first trimester pregnancy losses[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 566-571.
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