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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (4): 626-629    DOI: 10.12891/ceog4781.2019
Original Research Previous articles | Next articles
Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy
L. Wu1, †, M. Zheng2, †, M. Bao1, 2, X. Tong1, Y. Liu1, H. Han3, *()
1Center for Reproductive Medicine, Prenatal Diagnosis Center, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
2Anhui University of Traditional Chinese Medicine, Hefei, China
3Department of Neurology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China
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Abstract  

Purpose of Investigation: To report pregnancy outcome after decoppering therapy in patients with recurrent spontaneous abortion (RSA) and Wilson’s disease (WD). Materials and Methods: In a retrospective study, 12 WD patients who suffered from RSA were treated with dimercaptosuccinic acid and zinc gluconate. The average daily dose of dimercaptosuccinic acid and zinc gluconate was 1.00 and 1.68 grams, respectively. Dimercaptosuccinic acid was discontinued, while zinc gluconate was continued during pregnancy. The primary clinical outcomes were the pregnancy outcome after decoppering therapy and the mean age at diagnosis. Results: Six patients conceived at least once after treatment. Five of them had successful pregnancies with seven healthy live births. Mean age at diagnosis was significantly lower in patients who delivered healthy babies than in those who failed to conceive. Conclusions: Decoppering therapy is efficacious in reversing the pregnancy outcome of RSA in patients with WD, especially in the women who are diagnosed at young age. Age at diagnosis is an important risk factor that affects the pregnancy outcome in these patients.

Key words:  Pregnancy outcome      Recurrent spontaneous abortion      Wilson’s disease      Decoppering therapy     
Published:  10 August 2019     
Fund: Contributed equally.
*Corresponding Author(s):  H. HAN     E-mail:  46467654@qq.com

Cite this article: 

L. Wu, M. Zheng, M. Bao, X. Tong, Y. Liu, H. Han. Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 626-629.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4781.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I4/626

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