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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 752-756    DOI: 10.12891/ceog4747.2019
Original Research Previous articles | Next articles
Is there a relationship between systemic inflammatory markers and abnormal uterine bleeding in unclassifiable cases according to the PALM-COEIN system?
H. Aydoğmuş1, *(), S. Gençdal1, Z. Kolsuz1, F. Elmalı2, S. Aydoğmuş1, 3, S. Kelekçi4
1Department of Gynecology and Obstetrics, İzmir Katip çelebi University Atatürk Research and Training Hospital, İzmir, Turkey
2Department of Statistics, İzmir, Turkey
3Department of Gynaecology and Obstetrics, İzmir Katip çelebi University School of Medicine, İzmir, Turkey
4Department of Gynaecology and Obstetrics, Private Kordon Surgery Center, İzmir, Turkey
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Objective: The aim of this study is to assess the possibility of subclinical inflammation and the difference of SIR markers in cases with abnormal uterine bleeding (AUB). Materials and Methods: A total of 529 women were enrolled in the study. Patients were classified according to diagnostic categories of PALM-COEIN. The comparisons between the groups were analyzed by one way variant analysis and Kruskal-Wallis analysis. Relations between numerical variables were assessed by Spearman Correlation analysis. Results: No significant difference was found between the groups for SIR markers. When SIR markers were compared between the groups Neutrophil / lymphocyte ratio (NLR) was negatively correlated with lymphocyte/platelet ratio (LPR) in all the groups. Although a strong negative correlation was detected between NLR and lymphocyte/monocyte ratio (LMR) in Groups 2, 3, and 4, no significant relation was detected in Group 1. Conclusions: In this study, no significant difference of SIR markers was observed between AUB cases with functional or structural abnormalities and unclassifiable AUB cases according to PALM-COEIN classification.

Key words:  Abnormal uterine bleeding      Systemic inflammatory response markers      PALM-COEIN System     
Published:  10 October 2019     
*Corresponding Author(s):  H. AYDOĞMUŞ     E-mail:

Cite this article: 

H. Aydoğmuş, S. Gençdal, Z. Kolsuz, F. Elmalı, S. Aydoğmuş, S. Kelekçi. Is there a relationship between systemic inflammatory markers and abnormal uterine bleeding in unclassifiable cases according to the PALM-COEIN system?. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 752-756.

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