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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 727-730    DOI: 10.12891/ceog4741.2019
Original Research Previous articles | Next articles
Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation
P. Bakas1, *(), M. Simopoulou1, P. Panagopoulos2, N. Salakos1, Ch. Siristatidis2
12nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece
23rd Department of Obstetrics and Gynecology, Attiko Hospital, University of Athens, Athens, Greece
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Abstract  

Purpose of Investigation: To examine if the potential changes in progesterone (P) and estradiol (E2) levels during the luteal phase can predict the outcome in IVF/ICSI cycles. Material and Methods: A prospective study of 282 patients with infertility undergoing IVF/ICSI have been included. Serum E2 and P measurements at day of hCG triggering and days 6 and 10 after embryo transfer in conception and non-conception cycles. Results: The ROC curve in predicting clinical pregnancy was calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of ≤ 32 % demonstrated sensitivity of 84.3% and specificity of 80.4%. The corresponding ROC curve for percentage change in P levels was 0.733 with 95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2 levels between days 6 and 10 after embryo transfer demonstrated a predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with sensitivity 84.3% and specificity 80.4%.

Key words:  Estradiol      Progesterone      Ganirelix      Controlled ovarian stimulation      COS      IVF      ICSI     
Published:  10 October 2019     
*Corresponding Author(s):  P. BAKAS     E-mail:  pbakas74@gmail.com

Cite this article: 

P. Bakas, M. Simopoulou, P. Panagopoulos, N. Salakos, Ch. Siristatidis. Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 727-730.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4741.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/727

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