Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (4): 641-645    DOI: 10.12891/ceog4733.2019
Case Report Previous articles | Next articles
The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature
T. Yamashita1, N. Takayanagi1, M. Higashi1, S. Momose1, J. Tamaru1, *()
1Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan
Download:  PDF(628KB)  ( 196 ) Full text   ( 7 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

The occurrence of cavernous hemangiomas in the vagina is very rare. A 34-year-old woman at 33 weeks’ gestation was admitted with a large reddish mass of approximately 5 cm in diameter in the vagina, with bleeding and a sensation of discomfort with walking. The vaginal mass was excised to confirm the pathological diagnosis. Histopathological analysis showed various dilated vessels lined by increased endothelial cells, and the final diagnosis was vaginal cavernous hemangioma. The immunohistochemical analysis showed positive expressions of vascular endothelial growth factor (VEGF), estrogen receptor (ER), and progesterone receptor (PgR) in perivascular stromal cells around the hemangioma. Additionally, the authors reviewed the relationship between genital hemangiomas and pregnancy from the literature. In the female genital tract, six (75%) of eight vaginal hemangiomas were associated with pregnancy, in particular, late pregnancy, in addition to the present case, and eight (32%) of 25 cervical hemangiomas were seen in late pregnancy. Taken together, the hormonal status in late pregnancy may affect the formation of vaginal hemangiomas.

Key words:  Vagina      Hemangioma      Hormonal status      Pregnancy     
Published:  10 August 2019     
*Corresponding Author(s):  J. TAMARU     E-mail:  jtamaru@saitama-med.ac.jp

Cite this article: 

T. Yamashita, N. Takayanagi, M. Higashi, S. Momose, J. Tamaru. The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 641-645.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4733.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I4/641

[1] Mahvash Zargar, Razieh Pazhouhanfar, Mahin Najafian, Parastoo Moradi Choghakabodi. Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 179-184.
[2] Saipin Pongsatha, Theera Tongsong. Intravaginal misoprostol versus sublingual misoprostol for second trimester pregnancy termination: a randomized controlled trial[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 122-127.
[3] Eman A. Elhosary, Mahmoud M. Ewidea, Marwa A. Mohamed. Efficacy of kinesio tape on neck pain and functional disability in pregnant women: a randomized controlled trial[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 175-178.
[4] Xiao-Cen Niu, Li-Hua Zhu, Zhi-Da Qian, Li-Li Huang. Disseminated intravascular coagulation developed after suction curettage in an adenomyosis patient: a case report and literature review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 189-193.
[5] Khac Tu Chau, Minh Tam Le, Doan Tu Tran, Vu Quoc Huy Nguyen. Uterine torsion in a 25-week pregnant female with congenital uterine didelphys and intraoperative complication of uterine atony: a report of a rare clinical case[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 185-188.
[6] Ji Eun Park, Ji Kwon Park, Hyun Chul Jo, In Ae Cho, Jong Chul Baek. The association between antenatal corticosteroid use in late-preterm and early-term pregnancy and nonreassuring fetal status[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 79-84.
[7] Jing-Jing Jiang, Ting Han, Yan-Hui Zhu. The early second-trimester multifetal pregnancy reduction improves pregnancy outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 164-167.
[8] Sureyya Saridas Demir, Erkan Cağliyan, Sabahattin Altunyurt. Retrospective analysis of pregnancy terminations and indications in a tertiary center[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 85-90.
[9] R. Mihăilă. Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 814-820.
[10] G.S. Wang, B. Wei. Vaginal myomectomy is superior to abdominal myomectomy in treatment effect and postoperative recovery[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 840-846.
[11] C.W. Kim, D.H. Lee, B.S. Joo, K.S. Lee. Successful cryopreservation of mouse and human blastocysts using vitrification solution without sucrose and Ficoll[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 847-855.
[12] E. Destegül, S. Gençdal, İ. Sarı, H. Akkaya, B. Çakmak, N. Gençdal. Maternal serum levels of SCUBE1 in missed abortion[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 862-866.
[13] J.R. Huang, X. Li, Q.Z. Peng, J.J. Zhang, X.X. Lin, L.Q. Xie, X.H. Wu, W.S. Zhang. Elective embryo or fetal reduction for caesarean scar pregnancy combined with intrauterine pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 867-874.
[14] X.R. Wang, Y.F. Wang, S.W. Kang, Y. Zhang. Treatment outcomes of uterine lesion resection versus hysterectomy for cesarean scar pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 882-886.
[15] J.R. Huang, X. Li, C. Fu, Y.H. Deng, T. Gao, H.W. Zhang. Is preprocessing helpful for suction and curettage in treating cesarean scar pregnancy?[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 900-905.
[1] Paige McKenzie, Yunping Lei, Jessica Momb, Dean Appling, Richard H. Finnell. A Common Variant in MTHFD1L is Associated with Increased Risk for Spina Bifida[J]. Journal of Molecular and Clinical Medicine, 2018, 1(1): 19 -22 .
[2] Robert M Cabrera, Bogdan J, Wlodarczy k, Richard H. Finnell. Elucidation of Folate-Mediated Cascades in the Developing Neural Tube: Congenital Malformations Induced by Methyltransferase Inhibition[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 119 -126 .
[3] Jiriys George Ginini, Dekel Shilo, Omri Emodi, Adi Rachmiel. Low Intensity Pulsed Ultrasound for Accelerating Distraction Osteogenesis: A Systematic Review of Experimental Animal Studies[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 107 -114 .
[4] Zaher Bahouth, Yasmine Ghantous, Edmond Sabo, Omri Nativ, Sarel Halachmi, Boaz Moskovitz, Zaid Abassi, Ofer Nativ. The long-term functional impact of post-operative acute kidney injury in patients undergoing nephron-sparing surgery[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 115 -118 .
[5] Carla Ríos-Luci, Elena Díaz-Rodríguez, Rubén M. Buey, Inês J. Sousa, Miguel X. Fernandes, Atanasio Pandiella, José M. Padrón. A Small Molecule Tubulin Depolymerizing Agent Identified by a Phenotypic Drug Discovery Approach[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 67 -76 .
[6] Irene Lagunes, Elva Martín-Batista, Gastón Silveira-Dorta, Miguel X. Fernandes, José M. Padrón. Differential mechanism of action of the CK1$\varepsilon $ inhibitor GSD0054[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 77 -84 .
[7] Lana Eskander-Hashoul, Rina Elimelech, Zvi Gutmacher, Shai Frankenthal, Doron Rozitsky, Tal Tamari, Hadar Zigdon-Giladi. Extent of surgical trauma may not be a key factor in Medication-related osteonecrosis of the jaw -- a pilot study[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 85 -92 .
[8] Itay Levi, Michal Halperin-Sternfeld, Hadar Zigdon-Giladi, Eli E. Machtei, Jacob Horwitz. Dimensional changes of the alveolar ridge in the posterior maxilla and sinus pneumatization following teeth extraction[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 93 -98 .
[9] Nele Van Der Steen, Richard J Honeywell, Henk Dekker, Johan Van Meerloo, Jeroen Kole, René Musters, Rob Ruijtenbeek, Christian Rolfo, Patrick Pauwels, Godefridus J Peters, Elisa Giovannetti. Resistance to crizotinib in a cMET gene amplified tumor cell line is associated with impaired sequestration of crizotinib in lysosomes[J]. Journal of Molecular and Clinical Medicine, 2018, 1(2): 99 -106 .
[10] Evgeniy A. Cheremushkin, Nadezda E. Petrenko, Irina A. Yakovenko, Sergei A. Gordeev, Nikolay N. Alipov, Olga V. Sergeeva. Human neurophysiological markers of high anxiety level during preparation for visual recognition[J]. Journal of Integrative Neuroscience, 2018, 17(3): 193 -202 .