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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 713-722    DOI: 10.12891/ceog4711.2019
Original Research Previous articles | Next articles
Preliminary analysis of risk factors for congenital heart disease: a retrospective review of 145 cases in a single institution
Qianhong Liang1, *(), Wei Gong1, Dongming Zheng1, Risheng Zhong1, Yunjie Wen2, Xiaodan Wang2
1Ultrasound Department, China Panyu He Xian Memorial Hospital, Guangzhou, China
2Guangzhou Huayin Medical Labratory Center CO. Ltd, Guangzhou, China
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Background: Congenital anomaly is one of the most common cause of infant mortality and in China the incidence is quite high compared to other countries. It is therefore important to identify the potential risk factors of congenital problem such as congenital heart diseases. Materials and Methods: A retrospective study of 5,636 newborn cases from 2012 to 2014 in Panyu Maternal and Child Care Service Centre of Guangzhou was carried out, and among which 145 cases were confirmed for congenital heart defects. Review and analysis of maternal and paternal factors was performed using univariate and multivariate logistic regression analyses. Results: Several maternal factors were significantly associated with the occurrence of the congenital anomaly. However, after combining both maternal and paternal factors, only higher maternal age (OR = 1.076, 95% CI: 1.007-1.148, p = 0.029) and increased gravidity (OR = 1.153, 95% CI: 1.024-1.298, p = 0.018) were identified as risk factors whereas RBC count (OR = 0.374, 95% CI: 0.187-0.745, p = 0.005) was identified as a protective factor of the abnormal outcome using multivariate regression analysis. Conclusion: Further investigation on how the level of RBC in mother may contribute to the prevention of congenital heart disease is warranted.

Key words:  Congenital heart disease      Regression analysis      Maternal factor      Paternal factor      Retrospective analysis      Red blood cell count     
Published:  10 October 2019     
*Corresponding Author(s):  QIANHONG LIANG     E-mail:

Cite this article: 

Qianhong Liang, Wei Gong, Dongming Zheng, Risheng Zhong, Yunjie Wen, Xiaodan Wang. Preliminary analysis of risk factors for congenital heart disease: a retrospective review of 145 cases in a single institution. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 713-722.

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