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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (3): 356-358    DOI: 10.12891/ceog4703.2019
Original Research Previous articles | Next articles
Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer
J.H. Check1, 2, *(), C. Dietterich2, M. Lowney2, V. Sapoznikov2, R. Difilippo2, J. Giangreco2, K. Clarkson2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA
2Cooper Institute For Reproductive Hormonal Disorders, P.C., Mt. Laurel, NJ, USA
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Abstract  

Purpose: To determine if in the modern era failing to attain a homogenous hyperechogenic (HH) pattern three days after embryo transfer is still associated with a lower pregnancy rates. The study evaluates the efficacy of adding extra progesterone (P) at the time of the non-HH pattern. Materials and Methods: A five-year retrospective cohort analysis was performed evaluating two age groups (≤ 34 vs. 35-39 years). If an HH pattern was not attained, 50 mg IM P was added to the vaginal P supplementation already given in the IVF-ET cycle. The first two IVF cycles were evaluated. Results: There was no difference in live delivered pregnancy rates in younger women not attaining the HH pattern but it was lower in those aged 36-39 years. Conclusions: A randomized study adding extra IM P or not in women aged 36-39 or even the younger women is needed to determine if adding extra IM P improves the pregnancy rates or not.

Key words:  Mid-luteal phase      Endometrial echo pattern      In vitro fertilization      Live delivered pregnancy rate     
Published:  10 June 2019     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, C. Dietterich, M. Lowney, V. Sapoznikov, R. Difilippo, J. Giangreco, K. Clarkson. Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 356-358.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4703.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I3/356

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