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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (6): 876-880    DOI: 10.12891/ceog4686.2019
Original Research Previous articles | Next articles
Relationships between vitamin D receptor genetic polymorphisms and endometriosis in Korean women
H.-H. Lee1, †, M.-J. Mun2, 3, †, T.-H. Kim1, Y.-S. Kim1, 4, W.-C. Jang2, 3, J.-Y. Hwang5, *()
1Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea
2Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea
3Department of Chemistry, School of Natural Science, Dankook University, Cheonan, Republic of Korea
4Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea
5Department of Biomedical Engineering, College of Medicine, Korea University, Seoul, Republic of Korea
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Abstract  

Objectives: Vitamin D and vitamin D receptor (VDR) are closely associated with both various immune system functions and estrogen-related pathways. The authors hypothesized that VDR genetic polymorphisms are associated with endometriosis risk. In this casecontrol study, the authors investigated the associations between polymorphisms in the VDR gene (FokI, BsmI, ApaI, and TaqI) and endometriosis risk. Materials and Methods: This case-control study included 30 women with endometriosis and 30 women without endometriosis. Genotyping of VDR polymorphisms was conducted using polymerase chain reaction and DNA sequencing. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between the four VDR polymorphisms and endometriosis risk using Fisher's exact test. Results: The four VDR genetic polymorphisms showed no significant associations with endometriosis risk. Similarly, a combination analysis indicated that no combinations of polymorphisms were associated with endometriosis risk. However, the present analysis combining three polymorphisms revealed very low ORs (CGGT: 0.536, TGTT: 0.250, and CGTT: 0.321). Conclusion: The present results suggest that VDR polymorphisms do not affect endometriosis risk in Korean women. However, the genotype frequencies of ApaI and TaqI differed between endometriosis patients and controls. Therefore, it is necessary to further validate the relationship between VDR polymorphisms and endometriosis risk in large-scale samples.

Key words:  Vitamin D receptor      Polymorphism      Endometriosis     
Published:  10 December 2019     
*Corresponding Author(s):  J.-Y. HWANG     E-mail:  jyhwang@kctech.re.kr
About author:  Contributed equally.

Cite this article: 

H.-H. Lee, M.-J. Mun, T.-H. Kim, Y.-S. Kim, W.-C. Jang, J.-Y. Hwang. Relationships between vitamin D receptor genetic polymorphisms and endometriosis in Korean women. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 876-880.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4686.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I6/876

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