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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (3): 359-367    DOI: 10.12891/ceog4607.2019
Original Research Previous articles | Next articles
Novel inflammatory markers of labor following premature preterm rupture of membranes
R. Rzepka1, *(), B. Dołęgowska2, N. Marczuk2, S. Kwiatkowski1, A. Rajewska1, K. Nurek1, A. Torbè1
1Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
2Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland
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Abstract  

The aim of the study was comparison of levels of resistin (RE), soluble receptor for advanced glycation end products (sRAGE), soluble receptor activator for nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG), glucose (GL), total protein (TP), and albumin (AL) between women with preterm and term rupture of fetal membranes and evaluation of prognostic values of all above in diagnostic of premature labor. Ninety-eight women in singleton pregnancy presenting with premature rupture of fetal membranes were included and divided into two groups: A - 49 women after 37 weeks and B - 49 women before 36 weeks of gestation. Plasma levels of sRAGE, OPG, TP, and AL were significantly lower in group B, and RE and GL plasma levels were higher in this group. The high prognostic values for sRAGE and sRANKL in the prognosis of spontaneous delivery after preterm rupture of membranes (pPROM) were found. The authors concluded that sRAGE and sRANKL serum levels could be a useful prognostic factors after pPROM. Resistin can play role in pathogenesis of rupture of membranes in premature pregnancy.

Key words:  Preterm labour      Resistin      sRAGE      esRAGE      sRANKL     
Published:  10 June 2019     
*Corresponding Author(s):  R. RZEPKA     E-mail:  rafalrz123@gmail.com

Cite this article: 

R. Rzepka, B. Dołęgowska, N. Marczuk, S. Kwiatkowski, A. Rajewska, K. Nurek, A. Torbè. Novel inflammatory markers of labor following premature preterm rupture of membranes. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 359-367.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4607.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I3/359

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