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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (4): 553-559    DOI: 10.12891/ceog4600.2019
Original Research Previous articles | Next articles
Genome-wide association study of recurrent endometriosis related with ovarian cancer
Y.-S. Kim1, †, J.-Y. Hwang2, †, T.-H. Kim3, E.-G. Lee1, H.-H. Lee3, *()
1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan
2Department of Biomedical Engineering, College of Medicine, Korea University, Seoul
3Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon (Republic of Korea)
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Abstract  

Purpose: Endometriosis is a painful and chronic gynecological disease affecting approximately 10% of reproductiveage women and has an increasing rate of recurrence. However, studies of recurrent endometriosis are lacking. Ovarian cancer is related to recurrent endometriosis. In this study, the authors’ objectives were to determine whether DNA mutations or variants observed in endometriosis are involved in recurrence and whether genome-wide sequences in recurrent endometriosis tissues are related to DNA mutation patterns of known ovarian cancer cluster genes. Materials and Methods: The authors collected two recurrent endometriosis tissue samples in which the patients had severe endometriosis with greater than revised American Society for Reproductive Medicine (rASRM) classification stage 3. They then conducted target next-generation sequencing (NGS). A library was constructed, and the data were compared to those from a comprehensive cancer panel (CCP). Results: The bioinformatics analysis revealed 39 gene mutations with significant frequency in the two recurrent endometriosis samples. However, the DNA mutations associated with recurrent endometriosis differed from the CCP variants. Discussion: The genes identified herein are associated with DNA repair, transcription, fibrosis, and proliferation in the endometrium and ovary-induced endometriosis or ovarian carcinoma.

Key words:  Endometriosis      Recurrence      Ovarian neoplasm      Next-generation sequencing     
Published:  10 August 2019     
Fund: Contributed equally.
*Corresponding Author(s):  H.-H. LEE     E-mail:  hhl22@schmc.ac.kr

Cite this article: 

Y.-S. Kim, J.-Y. Hwang, T.-H. Kim, E.-G. Lee, H.-H. Lee. Genome-wide association study of recurrent endometriosis related with ovarian cancer. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 553-559.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4600.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I4/553

[1] Xiao Zhang, Ying-Ying He, Nan Jiang, Zhi-Gang Sun, Feng Yan, Cidanyangzong, Fang Long, Fang-Xin Shi, Xiao-Guang Xu, Zhen Xiao. The infiltrating ability of abdominal wall endometriosis is associated with ectopic endometrial glandular activity[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 73-78.
[2] Masataka Ono, Junya Kojima, Ei Hasegawa, Yotaro Takaesu, Toru Sasaki, Hirotaka Nishi. Anti-Müllerian hormone levels following laparoscopic ovarian cystectomy with subcutaneous abdominal wall lifting for ovarian endometriomas[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 91-97.
[3] D. Filipecka-Tyczka, A. Kajdy, B.P. Siekierski, M. Stańczyk, A. Rogowski, M. Rabijewski, R.B. Maksym. Deep infiltrating endometriosis as a cause of severe urogynecological complications despite invasive treatment - report of two cases from the center of endometriosis surgery[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 955-960.
[4] S.H. Park, J. Lim, K.T. Lim, K.H. Choi, S.M. Yoon, H.J. Chung. Ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis, a type of limbic encephalitis: a review of the literature and a case report in korea[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 774-780.
[5] Y.A. Kim. Mature cystic teratoma of the uterus presenting as an endometrial polyp in a patient with a history of ovarian mature cystic teratoma with gliomatosis peritonei and ovarian endometriosis: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 800-804.
[6] H. Takagi, S. Yamada, J. Sakamoto, S. Fujita, T. Sasagawa. Hemostatic effects of kyukikyogaito in dienogest treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 560-564.
[7] K. Chmaj-Wierzchowska, M. Wojciechowska, I. Parda, K. Plagens-Rotman, P. Rzymski, M. Wilczak. How do health problems affect the quality and everyday life of patients with endometriomas?[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 571-575.
[8] X.J. Shi, L.B. Shi, S.Y. Zhang. Mechanistic study of vitamin C attenuation of endometriotic fibrosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 383-390.
[9] M. Ζafrakas, Κ. Κοtronis, P. Papasozomenou, P. Eskitzis, G. Grimbizis. Extracellular matrix metalloproteinases in the etiopathogenesis of endometriosis: a systematic review and critical appraisal[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 147-153.
[10] S.Y. Jung, H.Y. Cho, S.H. Lee, S. Lim, K.B. Lee. Pregnancy outcomes of a giant primary ovarian leiomyoma in the first trimester[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 135-138.
[11] K.Y. Yun, S.Y. Hwang, H.J. Lee, S.C. Kim, J.K. Joo, D.S. Suh, K.H. Kim, K.S. Lee. The association of body mass index with incidence, stage and recurrence of endometriosis: case-control study in Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 53-56.
[12] Hue HJ, Kim SK, Choi JY, Suh DH, Kim KD, No JH, Lee JR, Jee BC, Kim YB, Jeon HW. Previous ovarian surgery increases the risk of tubal factor infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 84-88.
[13] H.-H. Lee, M.-J. Mun, T.-H. Kim, Y.-S. Kim, W.-C. Jang, J.-Y. Hwang. Relationships between vitamin D receptor genetic polymorphisms and endometriosis in Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 876-880.
[14] A. Vitagliano, A. Andrisani, F. Dessole, G. Virdis, R. Cappadona, L. Marin, G. Capobianco, S. Dessole, G. Ambrosini. Rectovaginal endometriosis: head to head comparison between sonovaginography and magnetic resonance imaging[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 888-891.
[15] C. Hayashi, K. Matsumoto, K. Shinya, T. Nakajima, T. Nakao, A. Komatsu, F. Chishima, K. Kawana. The expression of angiotensin II receptors mRNA in granulosa-lutein cells in endometriosis patients who underwent ovarian surgery before in vitro fertilization[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 910-913.
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[2] Sandeep K. Krishnan, Norman E. Lepor. Acute and Chronic Cardiovascular Effects of Hyperkalemia: New Insights Into Prevention and Clinical Management[J]. Reviews in Cardiovascular Medicine, 2016, 17(S1): 9 -21 .
[3] Ibrahim Sidiqi, Patrick Alexander. Current Advances in Endovascular Therapy for Infrapopliteal Artery Disease[J]. Reviews in Cardiovascular Medicine, 2015, 16(1): 36 -50 .
[4] Peter Shalit. Management of Dyslipidemia in Patients With Human Immunodeficiency Virus[J]. Reviews in Cardiovascular Medicine, 2014, 15(S1): 38 -46 .
[5] Sophie Mavrogeni, Fabrizio Cantini, Gerald M. Pohost. Systemic Vasculitis: An Underestimated Cause of Heart Failure—Assessment by Cardiovascular Magnetic Resonance[J]. Reviews in Cardiovascular Medicine, 2013, 14(1): 49 -55 .
[6] George L. Smith. Appropriate Use Criteria: The Gold Standard, or a Mechanism for the Derogation of Clinical Judgment?[J]. Reviews in Cardiovascular Medicine, 2011, 12(2): 105 .
[7] Prabhjot Singh Nijjar, Anoop Parameswaran, Aman M. Amanullah. Evaluation of Anomalous Aortic Origins of the Coronaries by 64-Slice Cardiac Computed Tomography[J]. Reviews in Cardiovascular Medicine, 2007, 8(3): 175 -181 .
[8] . SELF-ASSESSMENT POST-TEST[J]. Reviews in Cardiovascular Medicine, 2006, 7(S2): 51 -52 .
[9] Alice K. Jacobs. Gender Differences in Coronary Revascularization: Does Age Make a Difference?[J]. Reviews in Cardiovascular Medicine, 2004, 5(1): 68 -70 .
[10] Jeffrey W. Moses, Stephane Carlier, Issam Moussa. Lesion Preparation Prior to Stenting[J]. Reviews in Cardiovascular Medicine, 2004, 5(S2): 16 -21 .