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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (2): 224-228    DOI: 10.12891/ceog4571.2018
Original Research Previous articles | Next articles
Long-term efficacy of intravesical instillation of hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: 36 months' follow-up
D. De Vita1, †, M. Madonia2, †, E. Coppola1, C. Sciorio3, S. Giordano5, S. Dessole4, G. Capobianco4, *()
1 Chronic Pelvic Pain Centre, Dep. of Obstetrics and Gynaecology, Ospedale S. Maria Della Speranza, Battipaglia, Italy
2 Institute of Urology, University of Sassari, Sassari, Italy
3 Ostetricia e Ginecologia, ASL Napoli 2 Nord, Naples, Italy
4 Gynecologic and Obstetric Clinic, Dep. of Surgical, Microsurgical and Medical Sciences, University of Sassari, Italy
5 Division of Plastic Surgery, Department of Surgery, Turku University Hospital, OS Turku, Finland
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Abstract  
Purpose of Investigation: To compare the efficacy and safety of intravesical instillation of hyaluronic acid/chondroitin sulfate with conventional long-term antibiotic prophylaxis in women with recurrent bacterial cystitis. Materials and Methods: In this analysis of a prospective study, where women with recurrent bacterial cystitis were randomised to intravesical hyaluronic acid 800 mg/chondroitin sulfate 1,000 mg (group 1) or long-term antibiotic prophylaxis (group 2 – control group), patients in group 1 were evaluated 36 months after treatment. Outcomes included cystitis recurrence, subjective pain symptoms based on a visual analogue scale (VAS), three-day voiding, pelvic pain and urgency/frequency symptoms (PUF scale), sexual function questionnaire, quality of life based on King’s Health Questionnaire (KHQ), maximum cystometric capacity (MCC), and adverse events. Results: Twelve women (mean ± standard deviation 59.3 ± 13.9 years old) underwent follow-up at 36 months after treatment. There were improvements in all efficacy evaluations at 36 months’ follow-up, with significantly favourable mean changes from baseline in cystitis frequency (–5.4 episodes/year; p < 0.001), three-day voiding (–10.7 voids; p = 0.002), urinary VAS (–6.7 points; p < 0.001), PUF (–14.2 points; p < 0.001), sexual function (–4.3 points; p < 0.001) and KHQ (–34.0; p < 0.001) scores, and MCC (+131.7; p < 0.001). No adverse events were reported. Conclusions: Intravesical hyaluronic acid/chondroitin sulfate significantly reduced cystitis recurrence and associated symptoms and was well tolerated in women with recurrent bacterial cystitis at 36 months’ after treatment.
Key words:  Chondroitin sulfate      Hyaluronic acid      Intravesical instillation      Recurrent bacterial cystitis      Recurrent urinary tract infection     
Published:  10 April 2018     
*Corresponding Author(s):  G. CAPOBIANCO     E-mail:  capobia@uniss.it
About author:  † Contributed equally.

Cite this article: 

D. De Vita, M. Madonia, E. Coppola, C. Sciorio, S. Giordano, S. Dessole, G. Capobianco. Long-term efficacy of intravesical instillation of hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: 36 months' follow-up. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 224-228.

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https://ceog.imrpress.com/EN/10.12891/ceog4571.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I2/224

[1] M. Madonia, T. Solinas, F. Podda, G. Capobianco, P. L. Cherchi, S. Dessole, G. Morgia. The efficacy of intravesical hyaluronic acid instillation in resistant bladder pain syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 170-173.
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