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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (1): 127-130    DOI: 10.12891/ceog4552.2019
Original Research Previous articles | Next articles
Assessment of ovarian reserve with anti-Mullerian hormone in women following allogeneic hematopoietic cell transplantation
A.H. Kaya1, *(), E. Tekgunduz1, S. Akpınar1, G. Bozdağ2, T.N. Yiğenoğlu1, A. Merdin1, S. Namdaroglu1, O. Kayıkcı1, F. Altuntaş1
1 Hematology Clinic and Bone Marrow Transplantation Unit, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
2 Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey
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Abstract  
Introduction: Severe ovarian failure and persistent infertility have could be seen in females following allogeneic hematopoietic cell transplantation (allo-HCT.) In this study, the authors aimed to determine the effectiveness of AMH on assessment of ovarian reserve in long-term survivors after allo-HCT. Material and Methods: Female patients, who underwent allo-HCT between August 2009 and February 2016, were retrospectively evaluated for ovarian capacity in long-term follow-up. Twenty-one female patients with a median age of 34 (22-45) years were included in the study. The serum levels of estrogen (E2), follicle stimulated hormone (FSH), luteinizing hormone (LH), and AMH were analysed. Results: The median duration of post-transplant follow-up was 37 (12-84) months. Primary ovarian failure (POF) was detected in eight (38,1%) and 19 (90,4%) cases in the pre-transplant and post-transplant period, respectively. It was found that no menstruation cycles were observed in 18 cases with low AMH levels. Discussion: Regular menstrual cycles may not guarantee the fertilization in the post-transplant period. Combined analysis of hormonal investigations, antral follicle count by vaginal USG, and evaluation of serum AMH levels may be preferred to demonstrate the presence of POF.
Key words:  Anti-Mullerian hormone      Ovarian reserve      Allogeneic stem cell transplantation     
Published:  10 February 2019     
*Corresponding Author(s):  A.H. KAYA     E-mail:  dr.alihakan@gmail.com

Cite this article: 

A.H. Kaya, E. Tekgunduz, S. Akpınar, G. Bozdağ, T.N. Yiğenoğlu, A. Merdin, S. Namdaroglu, O. Kayıkcı, F. Altuntaş. Assessment of ovarian reserve with anti-Mullerian hormone in women following allogeneic hematopoietic cell transplantation. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 127-130.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4552.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I1/127

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