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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (5): 762-766    DOI: 10.12891/ceog4426.2018
Original Research Previous articles | Next articles
Decreased levels of UBE2Q1 and CHIP in the placentas of infection related preterm birth
Qingyan Cao1, †, Jing Zhang1, †, Li Zhang1, Daijuan Chen1, 2, Bing Peng1, *()
1 Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China
2 West China School of Medicine, Sichuan University Chengdu, China
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Abstract  
Objective: To explore the role of ubiquitin proteasome system in the pathogenesis of infection related preterm birth. Materials and Methods: Thirteen women with spontaneous preterm delivery and 13 controls were included in present case-controlled study. The mRNA and protein levels of Ub-conjugating enzyme E2Q1 (UBE2Q1) and Carboxyl-terminus of Hsc70 interacting protein (CHIP) in the placenta were measured by immunohistochemistry, real-time RT-PCR, and Western blotting methods. Statistical significance (p < 0.05) was determined using student's t-test. Results: The mRNA levels of UBE2Q1 (0.48±0.05 vs. 0.67±0.07, p = 0.047) and CHIP (1.59±0.23 vs. 5.62±1.00, p = 0.002) in the placentas of preterm delivery were significant lower than those of term delivery. The protein levels of UBE2Q1 (0.64±0.09 vs. 1.49±0.22, p < 0.001) and CHIP (0.76±0.08 vs. 1.33±0.23, p = 0.001) in the placentas of preterm delivery were also significant lower than those of term delivery. Conclusions: Decreased mRNA and protein expression of UBE2Q1 and CHIP were both found in the syncytiotrophoblast and cytotrophoblast of placenta in preterm birth patients, which was speculated to play a role in the pathogenesis of infection related preterm birth.
Key words:  Ubiquitin proteasome system      UBE2Q1      CHIP      Infection      Preterm birth     
Published:  10 October 2018     
*Corresponding Author(s):  BING PENG     E-mail:  pengbin-a111@163.com
About author:  † Contributed equally.

Cite this article: 

Qingyan Cao, Jing Zhang, Li Zhang, Daijuan Chen, Bing Peng. Decreased levels of UBE2Q1 and CHIP in the placentas of infection related preterm birth. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 762-766.

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https://ceog.imrpress.com/EN/10.12891/ceog4426.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I5/762

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