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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (5): 797-799    DOI: 10.12891/ceog4401.2018
Case Report Previous articles |
Prenatal diagnosis of a complex chromosomal rearrangement involving five chromosomes
Bo Wang1, †, Dan Lu1, †, Zuliang Shi1, †, Jian Ke2, †, Qi Zhao4, Hongjun Li3, *()
1 Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
2 Department of Health Care, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
3 Department of Medical Ultrasonics, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, PR China
4 Department of Clinical Laboratory, Dongsheng Area People's Hospital, Ordos, Inner Mongolia, PR China
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Abstract  
The present authors report an exceptional complex chromosomal rearrangement involving five chromosomes. Cytogenetic analysis of cultured amniocytes revealed a unique karyotype of 46,X,t(X;13;9)(q13;q14;p22),t(3;6)(p13;q23) in 35/35 cultured amniocytes. Microarray- based comparative genomic hybridization (aCGH) revealed two microdeletions on chromosome Xq13.1-q13.2 and 13q14.2- q21.1 respectively. This study demonstrates the feasibility of using aCGH for prenatal diagnosis, especially in detecting subtle chromosomal abnormalities in high risk pregnancies.
Key words:  Karyotype analysis      aCGH      Reciprocal translocation      Prenatal diagnosis     
Published:  10 October 2018     
*Corresponding Author(s):  HONGJUN LI     E-mail:  89657471@qq.com
About author:  † Contributed equally.

Cite this article: 

Bo Wang, Dan Lu, Zuliang Shi, Jian Ke, Qi Zhao, Hongjun Li. Prenatal diagnosis of a complex chromosomal rearrangement involving five chromosomes. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 797-799.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4401.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I5/797

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