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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (6): 934-935    DOI: 10.12891/ceog4380.2017
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Amelioration of severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer following treatment with amphetamine salts
J.H. Check1, 2, *(), R. Cohen1, 2
1 Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Cooper Medical School of Rowan University Camden, NJ, USA
2 Cooper Institute for Reproductive and Hormonal Disorders, P.C., Mt. laurel, NJ, USA
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Abstract  
Purpose: To determine if treating with dextroamphetamine sulfate can relieve severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer. Materials and Methods: Dextroamphetamine sulfate 15 mg extended release capsules (as part of amphetamine salts) was prescribed. Results: Within one week the pruritus was completely dissipated and remained under total control for two months. She stopped the medication and the severe pruritus returned in three days. Resuming the amphetamine, the symptoms disappeared again and she has remained completely without symptoms for ten additional months while on medicine. Conclusions: It is not clear if the estrogen deficiency caused the pruritus by producing dry skin. Nevertheless, if a woman with estrogen deficiency complains of pruritus, but estrogen therapy is contraindicated, the treating physician could consider treating with dextroamphetamine sulfate. Of course this could be attempted in women with normal estrogen who have idiopathic pruritus in the absence of any noticeable skin lesions if other remediable causes, e.g., scabies, has been excluded.
Key words:  Estrogen deficiency      Aromatase inhibitor      Dextroamphetamine sulfate      Breast cancer     
Published:  10 December 2017     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, R. Cohen. Amelioration of severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer following treatment with amphetamine salts. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 934-935.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4380.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I6/934

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