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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (5): 687-691    DOI: 10.12891/ceog4352.2018
Original Research Previous articles | Next articles
Is calcium levofolinate pentahydrate more effective than folic acid in young healthy women before conception?
G. Giunta1, *()., C. Cardea2, M.G. Matarazzo1, M.M. Panella1, A.M.C. Rapisarda1, S. Caruso1, A. Cianci1
1 Department of General Surgery and Medical Surgical Specialties, Department of Obstetrics and Gynecology University of Catania, Policlinico G. Rodolico, Catania, Italy
2 Reproductive Medicine Unit, HERA Center, Sant'Agata li Battiati, Catania, Italy
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Purpose of investigation: To assess whether l,5-formyl-tetrahydrofolic (levofolinic acid, LV) is better than folic acid (FA) to increase serum folate and to reduce homocysteine in healthy young women during reproductive age. Materials and Methods: Folate deficiency is related to a number of pregnancy complications. FA is a synthetic compound that has no biological functions unless it is reduced to tetrahydrofolate. Supplementation of an active form such as LV, could be a better alternative. The authors performed an 8-week 1:1 randomized, open label clinical trial in 40 healthy women aged between 18-40 years, with daily 4 mg LV or 400 mcg FA supplementation. Results: Serum folate were increased after LV or FA supplementation, as compared to baseline, without any significant differences within the two groups (p = 0.8). Homocysteine levels were reduced in both groups, by 31.6% (p < 0.001) and 26.3% (p < 0.001) respectively, however the reduction was much relevant in the LV group (p < 0.001). Conclusions: Supplementation with LV seems to be more effective to reduce homocysteine levels.
Key words:  Folic acid      Levofolinic acid      Homocysteine      Folate     
Published:  10 October 2018     
*Corresponding Author(s):  G. GIUNTA     E-mail:

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G. Giunta, C. Cardea, M.G. Matarazzo, M.M. Panella, A.M.C. Rapisarda, S. Caruso, A. Cianci. Is calcium levofolinate pentahydrate more effective than folic acid in young healthy women before conception?. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 687-691.

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[2] L. Tahaineh, K. Nuseir, L.M. Al-Mehaisen. Medication use during pregnancy and drug information resources utilized by pregnant women in Jordan[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 70-76.
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