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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (1): 12-15    DOI: 10.12891/ceog4117.2019
Original Research Previous articles | Next articles
The relationship between vitamin D and IVF: a systematic review and meta-analysis
Chunjuan Shen1, Liping Wang1, *(), Xiaojie Wu1, Shuhui Mao1, Chunxia Fang1
1 Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China
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Abstract  
Vitamin D deficiency does not influence IVF outcomes, but is related to lower pregnancy and it is important to provide more reliable evidence on vitamin D in IVF due o the published studies which are strongly contradictory. Objectives: To explore the effect of vitamin D in IVF with a focus on the outcome of clinical pregnancy in published studies. Materials and Methods: The authors used PubMed, EMBASE, Web of knowledge (SCI), and Cochrane Library Methods to explore all studies that evaluate vitamin D levels and IVF outcomes until 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated for analyses. Result: The authors first classified two groups to investigate the influence of vitamin D in IVF. There was no significant difference with deficient vitamin D and IVF outcome (RR 0.88, 95% CI 0.74-1.04; I2 63%, seven trials; 1,865 participants). In addition, vitamin D deficiency also di not show a significant difference in IVF outcome (RR 0.91, 95 % CI 0.77–1.18, RR 0.91, 95% CI, 0.77-1.18; I2, 72 trials, 1,172 participants). Conclusion: There is no significance between vitamin D status (deficiency or replete) and IVF outcomes, but it was also found that vitamin D deficiency was inclined to lower IVF pregnancy outcome.
Key words:  Vitamin D deficient      vitamin D replete      IVF      Clinical pregnancy rate      Endometrium      Infertility      Embryo transfer      Cut-off values     
Published:  10 February 2019     
*Corresponding Author(s):  LIPING WANG     E-mail:  87604211@qq.com

Cite this article: 

Chunjuan Shen, Liping Wang, Xiaojie Wu, Shuhui Mao, Chunxia Fang. The relationship between vitamin D and IVF: a systematic review and meta-analysis. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 12-15.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4117.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I1/12

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