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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (3): 387-390    DOI: 10.12891/ceog4098.2018
Original Research Previous articles | Next articles
Clinical efficacy of levonorgestrel releasing intrauterine system for the treatment of adenomyosis in perimenopausal women
Ju-Qi Ma1, Chun-Fen Guo1, Ayshamgul Hasim2, *()
1 Department of Gynecology in the First Affiliated Hospital, Xinjiang Medical University, Urumqi, China
2 Department of Pathology, College of Basic Medicine, Xinjiang Medical University, Urumqi, China
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Abstract  
Background: The aim of this study was to evaluate the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of menorrhagia, dysmenorrhea, and poor quality of life caused by adenomyosis in perimenopausal women. Materials and Methods: Ninety-six women with menorrhagia, dysmenorrhea, and poor quality of life with adenomyosis in perimenopausal women were included and were invited to complete a SF-36 Health Survey. Excluded were cervical and endometrial lesions that underwent a Pap smear, transvaginal sonography, and endometrial biopsy. LNG-IUS was inserted in the postmenstrual phase. Blood loss was assessed by pictorial blood loss assessment chart (PBAC), and dysmenorrhea intensity was assessed by a visual analogue scale (VAS). The patients were followed up after one, three, six, 12, and after 18 months. The participations are asked to complete the short form 36 (SF- 36) health survey questionnaires. Results: The menstrual blood size was (60.287 ± 21.832) (41.186 ± 16.153), (30.988 ± 15.670), (19.238 ± 13.649), (16 ± 11.464) after treatment one, three, six, 12, and after 18 months, respectively, which reduced significantly compare with before treatment (88.691 ± 33.775, p < 0.05). The VAS of dysmenorrheal dropped continuously and significantly from the baseline score of (74.968 ± 15.889) to (38.797 ± 16.781), (24.857 ± 16.595), (15.840 ± 14.305), (10.784 ± 13.593), and (8.196 ± 12.919), respectively, after treatment one, three, six, 12, and after 18 months of the LNG-IUS insertion (p < 0.05). The results of SF-36 Health Survey shown the quality of life was significantly improved. Conclusion: These data suggest that LNG-IUS is a safe and effective option for reduces menorrhagia, relieve dysmenorrhea, and improve the quality of life in patients with adenomyosis from perimenopausal women.
Key words:        Levonorgestrel intrauterine system      Menorrhagia      Dysmenorrhea      Adenomyosis      Perimenopause      SF-36 Health Survey     
Published:  10 June 2018     
*Corresponding Author(s):  ASHBAUGH HAMIS     E-mail:  axiangu75@126.com

Cite this article: 

Ju-Qi Ma, Chun-Fen Guo, Ayshamgul Hasim. Clinical efficacy of levonorgestrel releasing intrauterine system for the treatment of adenomyosis in perimenopausal women. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 387-390.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4098.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I3/387

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