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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (6): 935-938    DOI: 10.12891/ceog4089.2018
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A successful pregnancy following 11 miscarriages in an unexplained recurrent pregnancy loss patient with thrombophilia: a case report and literature review
Xiaomin Kanga1, †, *(), Tongfei Wanga1, †, Shijin Xiaoa1, †, Aimin Zhaoa1
1 Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China
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Abstract  
Objective: To highlight the benefit of thrombophilia screening and antithrombotic therapy in consecutive unexplained pregnancy losses. Case Report: The authors presented a detailed description and follow-up of a 37-year-old patient with a history of 11 miscarriages between the sixth and eighth weeks of gestation. In her eighth pregnancy, she was considered as unexplained recurrent pregnancy loss (RPL) and received lymphocyte immunization. However, the patient still experienced subsequent four spontaneous abortions at the similar gestational age. In the outpatient departments, she was diagnosed as thrombophilia and then she received low molecular weight heparin (LMWH) subcutaneous daily injection after ovulation and 50 mg aspirin daily orally started two months before pregnancy until the 32nd week of gestation. At 36+2 gestational weeks, a male infant was born in good condition with weight of 3,410 grams. Conclusion: Early start of LMWH and aspirin decreases the incidence of miscarriage in women with unexplained RPL.
Key words:  Aspirin      Low molecular weight heparin      Unexplained recurrent pregnancy loss     
Published:  10 December 2018     
*Corresponding Author(s):  AIMIN ZHAO     E-mail:  zamzkh0526@126.com
About author:  † These authors contributed equally to this work.

Cite this article: 

Xiaomin Kanga, Tongfei Wanga, Shijin Xiaoa, Aimin Zhaoa. A successful pregnancy following 11 miscarriages in an unexplained recurrent pregnancy loss patient with thrombophilia: a case report and literature review. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 935-938.

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https://ceog.imrpress.com/EN/10.12891/ceog4089.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I6/935

[1] R. Csorba, P. Tsikouras, A. Bothou, S. Zervoudis, G. Iatrakis, X. Anthoulaki, D. Deuteraiou, A. Chalkidou, G. F. von Tempelhoff. Air travel during pregnancy: an update review and practical recommendation[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 862-866.
[2] T. Toporcer, T. Grendel, I. Uhrinová, S.F. Iannaccone, A. Grendelová, F. Sabol, J. Belák, S. Toporcerová. Effect of low molecular weight heparin on autotransplantation efficacy of ovarian tissues in rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 542-548.
[3] H. Alptekin, N. Alptekin, R. Selimoğlu, T. Cengiz, S. Barış. Inherited thrombophilia and thromboprophylaxis: a retrospective analysis of pregnancy outcomes in 106 patients[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 749-754.
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