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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (3): 437-440    DOI: 10.12891/ceog4076.2018
Original Research Previous articles | Next articles
Immune response to hepatitis B vaccine in children born to HBsAg positive mothers: a meta-regression analysis
D. Yulon1, C. Jianing1, L. Wenchao2, W. Yingfeng1, L. Chong1, W. Lin1, H. Xianliang1, D. Hongyan1, *()
1 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, China
2 Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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Abstract  
Purpose: Mother-to-child transmission (MTCT) is the main mode of spread of hepatitis B virus (HBV), worldwide. The authors performed a meta-analysis to compare the effects of three measures for prevention of MTCT. Materials and Methods: Medline (PubMed) was searched and experts were contacted for references. Odds ratio (OD) and 95% confidence intervals (CI) were used as measures of effect sizes. Results: A meta-analysis was performed on randomized controlled trials and non-randomized studies comparing the index of MTCT among five groups of pregnant women. Among infants born to HBsAg-positive mothers, there were no significant differences in anti-HBs positive rates between the vaccine-only group and combined-immunization group by age 8-12 months. In infants aged 7- 15 months and infants aged 16–24 months, anti-HBs positive rate was 92.6% and 84.0% respectively. Immunoprophylaxis failure rate in mother's age < 28 group was significantly higher than that of ≥ 28 group, and that in vaccine-only group was significantly higher than vaccine plus HBIG group. Conclusions: HBIG and HB vaccine as an immune prophylaxis in infants born to HBV carrier mothers, beginning after birth, is effective in preventing MTCT of HBV.
Key words:  HBV      Mother-to-child transmission (MTCT)      Hepatitis B immunoglobulin (HBIG)      HB vaccine     
Published:  10 June 2018     
*Corresponding Author(s):  HONGYAN DIAO     E-mail:  diaohy@zju.edu.cn

Cite this article: 

D. Yulong, C. Jianing, L. Wenchao, W. Yingfeng, L. Chong, W. Lin, H. Xianliang, D. Hongyan. Immune response to hepatitis B vaccine in children born to HBsAg positive mothers: a meta-regression analysis. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 437-440.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4076.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I3/437

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