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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (6): 916-919    DOI: 10.12891/ceog4054.2018
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Larsen syndrome: prenatal diagnosis – a report of three cases
Kwan Young Oh1, *(), Seung Yeon Kim2, Chan Hee Jin1, Seung Hyun Kim1, Yun Seok Yang1
1 Department of Obstetrics and Gynaecology, Eulji University Hospital, Daejeon, Republic of Korea
2 Department of Paediatrics, Eulji University Hospital, Daejeon, Republic of Korea
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Abstract  
Larsen syndrome is a rare congenital skeletal malformation (one in 100,000 births) caused by a generalized mesenchymal connective tissue disorder. This disorder leads to a broad spectrum of anomalies. Major diagnostic criteria are multiple dislocations of large joints (especially knees), short metacarpals with cylindrical non-tapering fingers, and anomalous facial features. Clinical spectrum is variable and it ranges from mild to lethal forms. Genetic aspect is also variable; sporadic occurrence as well as autosomal dominant and recessive inheritance have been described. In this study, the authors report on their experience\ by presenting three cases of Larsen syndrome diagnosed by prenatal ultrasound.
Key words:  Larsen syndrome      Multiple dislocations      Anomalous facial features      Prenatal ultrasound     
Published:  10 December 2018     
*Corresponding Author(s):  KWAN YOUNG OH     E-mail:  ohky5@eulji.ac.kr

Cite this article: 

Kwan Young Oh, Seung Yeon Kim, Chan Hee Jin, Seung Hyun Kim, Yun Seok Yang. Larsen syndrome: prenatal diagnosis – a report of three cases. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 916-919.

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https://ceog.imrpress.com/EN/10.12891/ceog4054.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I6/916

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