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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (4): 507-508    DOI: 10.12891/ceog4039.2017
Original Research | Next articles
A second successful pregnancy using oocytes from a woman with premature ovarian failure with embryos transferred to a gestational carrier
J. H. Check1, *(), R. Cohen2
1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA
2 Cooper Institute for Reproductive and Hormonal Disorders, P.C., Mt. Laurel, NJ, USA
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Abstract  Purpose: To describe a second successful pregnancy in a woman with premature ovarian failure who was successfully able to induce ovulation by restoring down-regulated follicle stimulating hormone (FSH) receptors, by lowering elevated FSH by inhibiting FSH release from the pituitary, by using ethinyl estradiol with subsequent stockpiling of embryos following in vitro fertilization (IVF) for subsequent future transfer to a gestational carrier. Materials and Methods: A day 3 eight-cell embryo obtained from a fertilized oocyte 10.5 years before was transferred to a gestational carrier. Results: The gestational carrier conceived and she successfully carried to six months to date. Conclusions: This is the first case of two successful pregnancies from the same woman with premature ovarian failure. Also, this is the longest an embryo derived from a woman in ovarian failure has been frozen leading to a successful pregnancy.
Key words:  Premature ovarian failure      Ethinyl estradiol      Gestational carrier      Frozen embryo transfer      Down-regulated FSH receptors     
Published:  10 August 2017     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J. H. Check, R. Cohen. A second successful pregnancy using oocytes from a woman with premature ovarian failure with embryos transferred to a gestational carrier. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 507-508.

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https://ceog.imrpress.com/EN/10.12891/ceog4039.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I4/507

[1] Y. Wu, L. Tong, L. Xiao. Artificial neural network models for prediction of premature ovarian failure[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 958-963.
[2] Jianping Zhang, Fang Yang, Yaoqin Wang, Yonglian Wang, Hongmei Liang, Xueqing Wu. Effect of differential endometrial injury timing on frozen-thawed embryo transfer pregnancy outcomes[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 118-122.
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