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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (3): 344-346    DOI: 10.12891/ceog3896.2018
Original Research Previous articles | Next articles
Intra-cervical misoprostol for the treatment of second-trimester fetal demise
A.A. Rouzi1, *(), N. AlSinani1, N. AlMansouri1, N. Alsahly1
1 Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia
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Abstract  
Purpose: Misoprostol has gained wide use in the treatment of reproductive disease. Previous applications have been administered through oral or vaginal routes. The efficacy of intra-cervical administration is not well studied. The authors report the outcome of intracervical administration of misoprostol in three women treated for termination of second-trimester fetal demise. Materials and Methods: Three women with second-trimester fetal demise were treated using 50 μg of misoprostol administered in the cervical os. Results: Complete abortion was observed by 17 hours, ten hours and 15 minutes, and seven hours and 35 minutes, respectively. Two women received oral non-steroidal anti-inflammatory drugs for mild abdominal pain and one woman received intramuscular opiates for moderate to severe abdominal pain. There were no adverse side effects or complications of treatment. Conclusions: Intra-cervical misoprostol was useful in the termination of second-trimester fetal demise. The dose required was much less than that used for oral or vaginal administration. Further studies are needed to confirm the present findings.
Key words:  Second-trimester      Abortion      Misoprostol     
Published:  10 June 2018     
*Corresponding Author(s):  A.A. ROUZI     E-mail:  aarouzi@gmail.com

Cite this article: 

A.A. Rouzi, N. AlSinani, N. AlMansouri, N. Alsahly. Intra-cervical misoprostol for the treatment of second-trimester fetal demise. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 344-346.

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https://ceog.imrpress.com/EN/10.12891/ceog3896.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I3/344

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