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| Levels of EG-VEGF and VEGF in serum and in the follicular fluid on the day of oocyte retrieval and reproductive outcome among IVF patients |
A.J. Jakimiuk1, 2, *( ), M.A. Nowicka3, M. Zagozda2, K. Koziol4, P. Lewandowski4, T. Issat2, 3 |
1 Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland
2 Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
3 Department of Obstetrics, Women's Diseases and Oncogynecology, Central Clinical Hospital of Ministry of Interior and Administration, Warsaw, Poland
4 Novum, Fertility Clinic, Warsaw, Poland |
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Abstract
The aim of this retrospective, observational, case control study was to investigate the correlation of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and vascular endothelial growth factor (VEGF) concentrations in serum and follicular fluid (FF) in women undergoing controlled ovarian hyperstimulation (COH) protocols and IVF/ICSI with the reproductive outcome. When the authors compared levels of EG-VEGF and VEGF in FF and serum, they did not observe differences in the group without pregnancy compared to the group of patients with clinical pregnancy (EG-VEGF, respectively, p = 0.12, p = 0.94, and p = 0.16 and VEGF p = 0.16, p = 0.6, and p = 0.32). The authors found lower levels of EG-VEGF in FF from large follicles in the group of patients with clinical pregnancy who miscarried compared to the group of patients who had no pregnancy (p = 0.04); when they compared this group with the group of patients who delivered a baby, there was no statistical significance. Lower levels of EG-VEGF in the follicular fluid from large follicles are negatively correlated with positive outcome of IVF, and correlate with miscarriage rates in patients after IVF.
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Published: 10 February 2018
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*Corresponding Author(s):
A.J. JAKIMIUK
E-mail: jakimiuk@yahoo.com
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2018, Vol. 45 
