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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (1): 93-97    DOI: 10.12891/ceog3836.2018
Original Research Previous articles | Next articles
Levels of EG-VEGF and VEGF in serum and in the follicular fluid on the day of oocyte retrieval and reproductive outcome among IVF patients
A.J. Jakimiuk1, 2, *(), M.A. Nowicka3, M. Zagozda2, K. Koziol4, P. Lewandowski4, T. Issat2, 3
1 Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland
2 Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
3 Department of Obstetrics, Women's Diseases and Oncogynecology, Central Clinical Hospital of Ministry of Interior and Administration, Warsaw, Poland
4 Novum, Fertility Clinic, Warsaw, Poland
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Abstract  
The aim of this retrospective, observational, case control study was to investigate the correlation of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and vascular endothelial growth factor (VEGF) concentrations in serum and follicular fluid (FF) in women undergoing controlled ovarian hyperstimulation (COH) protocols and IVF/ICSI with the reproductive outcome. When the authors compared levels of EG-VEGF and VEGF in FF and serum, they did not observe differences in the group without pregnancy compared to the group of patients with clinical pregnancy (EG-VEGF, respectively, p = 0.12, p = 0.94, and p = 0.16 and VEGF p = 0.16, p = 0.6, and p = 0.32). The authors found lower levels of EG-VEGF in FF from large follicles in the group of patients with clinical pregnancy who miscarried compared to the group of patients who had no pregnancy (p = 0.04); when they compared this group with the group of patients who delivered a baby, there was no statistical significance. Lower levels of EG-VEGF in the follicular fluid from large follicles are negatively correlated with positive outcome of IVF, and correlate with miscarriage rates in patients after IVF.
Key words:  Vascular endothelial growth factor      Endocrine gland-derived vascular endothelial growth factor      Controlled ovarian hyperstimulation      IVF/ICSI      Pregnancy     
Published:  10 February 2018     
*Corresponding Author(s):  A.J. JAKIMIUK     E-mail:  jakimiuk@yahoo.com

Cite this article: 

A.J. Jakimiuk, M.A. Nowicka, M. Zagozda, K. Koziol, P. Lewandowski, T. Issat. Levels of EG-VEGF and VEGF in serum and in the follicular fluid on the day of oocyte retrieval and reproductive outcome among IVF patients. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(1): 93-97.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3836.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I1/93

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