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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (2): 218-223    DOI: 10.12891/ceog3818.2018
Original Research Previous articles | Next articles
Maternal, fetal outcome, and anticoagulant management in pregnant women with prosthetic heart valves
A. Akyol, M. Yaman1, *(), M. Şahin1, H. Şimşek1, S. Akdağ1, H. A. Gümrükçüoğlu1, A. Güler2, F. Öztürk1, F. Nur Gümrükçüoğlu3, M. Tuncer1
1 Cardiology Department, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
2 Mustafa Kemal University, Faculty of Medicine, Gynecology and Obstetry Department, Hatay, Turkey
3 Anatomy Department, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
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Abstract  
Introduction: Cardiac disease in maternity is a great problem particularly in developing countries. Pregnant patients with prosthetic heart valves (PHV) may suffer therapeutic difficulty, as the need for anticoagulation is fraught with risk of hemorrhagic or thromboembolic complications and structural valve deterioration. The present study aimed to evaluate the maternal, fetal outcome, and anticoagulant management in pregnant women with PHV. Materials and Methods: This study is prospective observational research. The medical archives of pregnant patients with PHV from September 2010 to January 2015 were scanned. Data collected from Yuzuncu Yıl University Hospital Cardiology clinics archives included demographic characteristics, anticoagulant, presence or absence of obstructive or non-obstructive thrombus, and maternal-fetal outcome. Results: The authors evaluated the outcomes of 56 pregnant patients with PHV. The age at the time of pregnancy ranged between 19 and 37 (mean 28.7 ± 8.4) years. Most common preferred anticoagulation therapy was heparin during the first trimester, followed by oral anticoagulation up to the 36th week, with subsequent replacement by heparin until delivery. Most common encountered complication was preterm birth. Death occurred in one patient due to obstructive valve thrombosis. Conclusion: Ideal PHV is not accessible for women during childbearing age. The risk of adverse event during pregnancy depends on valve position, symptoms, valve type, cardiac function, and functional capacity in patients with PHV. The active collaboration among an obstetrician, a cardiologist, and a cardiothoracic surgeon is required for optimal outcome patient with PHV.
Key words:  Pregnancy      Prosthetic heart valve      Anticoagulation     
Published:  10 April 2018     
*Corresponding Author(s):  M. YAMAN     E-mail:  dr.yaman@windowslive.com

Cite this article: 

A. Akyol, M. Yaman, M. Şahin, H. Şimşek, S. Akdağ, H. A. Gümrükçüoğlu, A. Güler, F. Öztürk, F. Nur Gümrükçüoğlu, M. Tuncer. Maternal, fetal outcome, and anticoagulant management in pregnant women with prosthetic heart valves. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 218-223.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3818.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I2/218

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