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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (2): 174-177    DOI: 10.12891/ceog3796.2018
Original Research Previous articles | Next articles
Expression of heparanase in the spontaneously aborted human chorionic villus
Yaqin Mu1, Jian Wang1, Runhua Liu1, Caixia Qi2, Guoping Xi2, Fuxi Zhao1, Zhuangyan Zhu2, *()
1 Institute of Immunology, Shanxi Datong University School of Medicine, Datong, China
2 Department of Obstetrics and Gynecology, Shanxi Datong University School of Medicine, Datong, China
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Abstract  
Objective: Heparan sulfate proteoglycans (HSPG) are main components of remodeling the extracellular matrix (ECM). Heparanase (HPSE) can cleave the HSPG and alter the structural integrity of the ECM. The present research was to investigate the role of HPSE in recurrent spontaneous abortion (RSA). Study Design: Reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical methods were used to determine the expression of heparanase (HPSE) in the villus of the human normal pregnancy and RSA. Results: The expressions of HPSE mRNA and protein in the normal group were significantly greater in comparison with those in the spontaneous abortion group (p < 0.05). Conclusion: The HPSE participates in the procedure of normal pregnancy, and the lower expression of HPSE may lead to the spontaneous abortion.
Key words:  Recurrent spontaneous abortion      HPSE      Reverse transcription-PCR      Immunohistochemical methods     
Published:  10 April 2018     
*Corresponding Author(s):  ZHUANGYAN ZHU     E-mail:  zzyzljzj@163.com

Cite this article: 

Yaqin Mu, Jian Wang, Runhua Liu, Caixia Qi, Guoping Xi, Fuxi Zhao, Zhuangyan Zhu. Expression of heparanase in the spontaneously aborted human chorionic villus. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 174-177.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3796.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I2/174

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[4] Yi Ling, Yuanhua Huang, Caixia Chen, Jilong Mao, Hongyu Zhang. Low dose Cyclosporin A treatment increases live birth rate of unexplained recurrent abortion - initial cohort study[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(2): 230-235.
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