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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (1): 39-43    DOI: 10.12891/ceog3723.2018
Original Research Previous articles | Next articles
A comparison in vitamin D receptor expression during oral menopausal hormone therapy and vaginal estrogen therapy
T.H. Kim1, H.H. Lee1, *(), J.M. Kim2, A. Lee3, J. Park4, Y. Kim3
1 Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea
2 Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea
3 Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea
4 Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute Science and Technology, Daejeon, Republic of Korea
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Abstract  
Objective: The aim of this study was to examine vitamin D receptor (VDR) expression in vaginal cell and vaginal maturation index (MI) of menopausal women after hormone replacement therapy (HRT). Materials and Methods: The authors enrolled 60 healthy postmenopausal women at one year after diagnosis of menopause who had no history of HRT. The subjects were randomized into two groups in an open label fashion. The oral HRT group was treated with one tablet (two mg drospirenone, one mg estradiol hemihydrate per tablet) per day for four weeks, and the vaginal estrogen therapy (ET) group used one vaginal suppository (500 μg estriol per tablet) every day over four weeks. The authors evaluated clinical characteristics, Kupperman index, and vaginal pH before and after treatment. Vaginal epithelial cells were obtained by vaginal swab and prepared to determine the vaginal MI or VDR expression using immunocytochemistry (ICC) and immunofluorescence, followed by confocal microscopy before and after treatment. Results: The authors confirmed cytoplasmic expression of VDR in vaginal epithelial cells and that VDR expression was increased in the vaginal epithelium after both oral HRT and vaginal ET, although VDR expression after oral HRT was more effective in increasing VDR than vaginal ET. Conclusion: VDR expression in the vagina is affected by different types of HRT.
Key words:  Intravaginal      Estradiol      Estriol      Hormone replacement therapy      Receptors      Calcitriol     
Published:  10 February 2018     
*Corresponding Author(s):  H.H. LEE     E-mail:  hhl22@schmc.ac.kr

Cite this article: 

T.H. Kim, H.H. Lee, J.M. Kim, A. Lee, J. Park, Y. Kim. A comparison in vitamin D receptor expression during oral menopausal hormone therapy and vaginal estrogen therapy. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(1): 39-43.

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https://ceog.imrpress.com/EN/10.12891/ceog3723.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I1/39

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