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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (1): 44-47    DOI: 10.12891/ceog3704.2018
Original Research Previous articles | Next articles
Outcome and recurrence risk of premature progesterone rise in IVF/ICSI cycles using GnRH antagonists for pituitary down-regulation
P. Bakas1, *(), M. Creatsa1, P. Panagopoulos2, N. Vlahos1, E. Papadakis1, M. Simopoulou1
1 2nd Department, Aretaieion Hospital, University of Athens, Athens, Greece
2 3rd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece
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Abstract  
Summary: To assess the outcome and recurrence risk of premature progesterone rise (PPRR) in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles using gonadotropin-releasing hormone (GnRH) antagonists. Materials and Methods: Two hundred and two patients undergoing IVF/ICSI using GnRH antagonists for pituitary down-regulation had measurements of luteinizing hormone (LH), progesterone (P), and estradiol (E2) on specific days of the first and subsequent stimulation cycle. Results: The overall clinical pregnancy rate including the total of 280 cycles was 29.3% (82/280). The incidence of PPRR on the day of triggering for P ≥ 1.5 ng/ml its was 20.8% (42/202). The risk of PPRR ≥ 1.5 ng/ml on the triggering day of the subsequent cycle was 40% if the previous cycle P was ≥ 1.5 ng/ml, 13.3% if the previous cycle P was ≥ 1.2 ng/ml and < 1.5 ng/ml, and 10% if the previous cycle P was < 1.2 ng/ml. Conclusion: The presence of PPRR in IVF/ICSI cycles using GnRH antagonists affects negatively the pregnancy rates and poses a significant risk of recurrence in a subsequent cycle.
Key words:  GnRH antagonist      Ganirelix      Ovarian stimulation      Premature progesterone      IVF      ICSI     
Published:  10 February 2018     
*Corresponding Author(s):  P. BAKAS     E-mail:  p_bakas@yahoo.com

Cite this article: 

P. Bakas, M. Creatsa, P. Panagopoulos, N. Vlahos, E. Papadakis, M. Simopoulou. Outcome and recurrence risk of premature progesterone rise in IVF/ICSI cycles using GnRH antagonists for pituitary down-regulation. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(1): 44-47.

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https://ceog.imrpress.com/EN/10.12891/ceog3704.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I1/44

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