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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (5): 740-743    DOI: 10.12891/ceog3613.2017
Original Research Previous articles | Next articles
Roles of high-risk human papilloma virus (HR-HPV) E6/E7mRNA in triaging HPV16/18 cases
L. Liu1, Y.M. Chen1, Q.Y. Zhang1, C.Z. Li1, *()
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
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Abstract  
Objective: This study aimed to investigate the roles of high-risk human papilloma virus (HR-HPV) E6/E7mRNA in triaging patients negative for intraepithelial lesion (NILM) accompanied with HPV16/18 infection. Materials and Methods: A total of 514 female patients simultaneously underwent cytological assay, HPV-DNA assay, E6/E7mRNA detection, and colposcopic biopsy were selected. The study endpoint was the histologically confirmed high-grade cervical intraepithelial neoplasia (CIN) II or higher(II+). Results: The positive rates of E6/E7mRNA in histopathologically confirmed cervicitis, CIN I, CIN II, CIN III, and cervical cancer were 53.4%, 66.7%, 89.9%, 91.4%, and 100%, respectively. Among the patients that underwent the colposcopic biopsy due to cytological NILM plus HPV16/18 infection, the positive predictive values of HPV16/18 and E6/E7mRNA towards high-grade cervical lesions were 21.5% and 40.4%, respectively, and the comparison between these two factors showed statistically significant difference (p < 0.05). The negative predictive value of E6/E7mRNA was 97.8%. Conclusions: E6/E7mRNA showed good triaging effects towards the patients with cytological NILM plus HPV16/18 infection and could significantly reduce colposcopy and biopsy.
Key words:  Cervical cancer      Screening      E6/E7mRNA      HPV.     
Published:  10 October 2017     
*Corresponding Author(s):  C.Z. LI     E-mail:  zhangzhonglidc@163.com

Cite this article: 

L. Liu, Y.M. Chen, Q.Y. Zhang, C.Z. Li. Roles of high-risk human papilloma virus (HR-HPV) E6/E7mRNA in triaging HPV16/18 cases. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 740-743.

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https://ceog.imrpress.com/EN/10.12891/ceog3613.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I5/740

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