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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (6): 847-850    DOI: 10.12891/ceog3498.2017
Original Research Previous articles | Next articles
Effects of levothyroxine on pregnancy outcomes and caveolin-1 expression in rat models of thyroid dysfunction
B.J. Du1, 2, C.H. Wang1, *(), C. Huang2, Z.Q. Li1
1 Shenzhen Maternal and Children Health Care Hospital of Southern Medical University, Shenzhen, China
2 Obstetrics Department, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Abstract  
To investigate the effect of thyroid hormone levothyroxine (L-T4 ) on pregnancy outcomes and expression of caveolin-1 in rat models of thyroid dysfunction. Materials and Methods: One hundred Wistar rats (SPE grade, 60 female and 40 male) were randomly divided into three groups of control, model (hypothyroidism), and treatment (hypothyroidism + therapy with L-T4 ) groups. Pregnant rats were investigated for pregnancy outcomes (litter size, number of dead fetus, placental index, body weight and length, and tail length of neonatal rat). Expression of caveolin-1 in placenta was analyzed using qRT- PCR and Western blot. Results: The modeling success rate was 75%. Investigations showed that the litter size, number of dead fetus, placental index, body and length, and tail length of neonatal rat in the models were significantly lower than those in control rats (p < 0.05), and significantly different from those in the treatment group (p < 0.05) except for the tail length (p > 0.05). The expression level of caveolin-1 in placenta was significantly higher in models than that in control (p < 0.05). Conclusion: Propylthiouracil (PTU) can successfully induce hypothyroidism in rat and hypothyroidism can seriously hinder the pregnancy process, resulting in developmental disorders in fetal rat.
Key words:  Thyroid hormone      Thyroid function      Caveolin-1      Gene expression      Pregnancy fate     
Published:  10 December 2017     
*Corresponding Author(s):  C.H. WANG     E-mail:  wangchenhong09@sina.com

Cite this article: 

B.J. Du, C.H. Wang, C. Huang, Z.Q. Li. Effects of levothyroxine on pregnancy outcomes and caveolin-1 expression in rat models of thyroid dysfunction. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 847-850.

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https://ceog.imrpress.com/EN/10.12891/ceog3498.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I6/847

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