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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (5): 730-733    DOI: 10.12891/ceog3478.2017
Original Research Previous articles | Next articles
Significance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates
S.Y. Tunc1, *(), N.Y. Goruk2, E. Agacayak1, M.S. Icen1, F.M. Findik1, H. Kusen3, M.S. Evsen1, H. Yuksel4, T. Gul1
1 Department of Obstetrics & Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey
2 Department of Obstetrics & Gynecology, Memorial Hospital, Diyarbakir, Turkey
3 Department of Obstetrics & Gynecology, Sirnak State Hospital, Sirnak, Turkey
4 Department of Medical Biochemistry, Dicle University School of Medicine, Diyarbakir, Turkey
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Abstract  
Purpose: To investigate the levels of growth differentiation factor-15 (GDF-15) in primary ovarian insufficiency (POI) and to evaluate its correlation with hormonal, biochemical, and inflammatory indicators. Materials and Methods: This comparative, cross-sectional study was carried out in 60 cases consisting of 30 healthy controls (mean age: 29.2 ± 5.0 years) and 30 patients with POI (mean age: 28.9 ± 6.8 years). Two groups were compared in terms of serum levels of glucose, lipids, thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), GDF-15, and neutrophil-lymphocyte ratios (NLR). Correlation between GDF-15 and NLR with these variables was sought. Results: Serum levels of FSH (p < 0.001), LH (p < 0.001), NLR (p < 0.001) and TSH (p = 0.020) were increased significantly in POI group. In POI patients, a correlation was detected between levels of GDF-15 levels and PRL (p = 0.049). Conclusion: The authors suggest that NLR can serve as a promising marker for diagnosis and follow-up of POI, whereas GDF-15 seems not to have such a potential.
Key words:  Primary ovarian insufficiency      Growth differentiation factor-15      Neutrophil lymphocyte ratio      Inflammation     
Published:  10 October 2017     
*Corresponding Author(s):  S.Y. TUNC     E-mail:  drsenemtunc@hotmail.com

Cite this article: 

S.Y. Tunc, N.Y. Goruk, E. Agacayak, M.S. Icen, F.M. Findik, H. Kusen, M.S. Evsen, H. Yuksel, T. Gul. Significance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 730-733.

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https://ceog.imrpress.com/EN/10.12891/ceog3478.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I5/730

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[2] J.H. Check, E. Chang. No evidence to support the concept that endometrial polyps impair fertility in the majority of cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 159-162.
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