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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (3): 408-412    DOI: 10.12891/ceog3406.2017
Original Research Previous articles | Next articles
Ultrasonography of fetal cleft lip and palate in first-trimester
H.L. Liu1, F. Yan1, H.P. Sun1, G.Q. Li1, F. Ai1, X.D. Dong1, *()
1 Department of Obstetrics, The First People's Hospital of Yunnan, Affiliated Hospital of Medical School, Kunming University of Science and Technology, Kunming, China
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Abstract  Purpose of Investigation: To explore the ultrasonographic methods towards cleft lip and palate (CLP) in first-trimester. Materials and Methods: 3,795 fetuses were scanned for facial structures including cross section of upper alveolar process, oblique coronal section of upper lip, and postnasal triangle section when measuring nuchal translucency (NT). The abnormal cases underwent ultrasonography for clear diagnosis at 17-18 gestational weeks (GWs), while the negative cases underwent systemic ultrasonography at 20-26 GWs, and followed up until birth. Results: Among the 3795 fetuses, 16 cases had CLP, with an incidence rate as 4.2%; 12 were detected in firsttrimester, with a detection rate of 75%, and the detection rate of bilateral CLP was 100%, four were missed, with a misdiagnosis rate of 25%, and 12 cases examined at 17-18 GWs met first-trimester diagnosis. Among the four missed cases, two were diagnosed with systemic ultrasonography, and two were diagnosed postnatally. All cases were confirmed after induction of labor or after birth. Conclusions: Ultrasonography in first-trimester could diagnose severe case of CLP.
Key words:  Cleft lip and palate      First-trimester      Congenital      Fetus      Ultrasonography     
Published:  10 June 2017     
*Corresponding Author(s):  X.D. DONG     E-mail:  xudongdongcn@126.com

Cite this article: 

H.L. Liu, F. Yan, H.P. Sun, G.Q. Li, F. Ai, X.D. Dong. Ultrasonography of fetal cleft lip and palate in first-trimester. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 408-412.

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https://ceog.imrpress.com/EN/10.12891/ceog3406.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I3/408

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