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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (6): 849-852    DOI: 10.12891/ceog3390.2016
Original Research Previous articles | Next articles
Immunohistochemical expression of hormonal receptors, collagen, elastin, and proteoglycans in genuine urinary incontinence
E. Pantatosakis1, *(), D. Karandrea2, E. Liapis3, A. Kondi-Pafiti4, A. Liapis5
1Aretaieion Hospital, Athens
2Pathology Department, Aretaieion Hospital, Athens
3Mitera Maternity Hospital, Athens
4Pathology Laboratory, Aretaieion Hospital, Athens
5Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens (Greece)
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Abstract  
Purpose: To study the expression of hormonal receptors, collagen, elastin, proteoglycans, and VIP in the vaginal wall of women with stress urinary incontinence (SUI). Materials and Methods: Fifty-eight specimens of the anterior vaginal wall (28 women with SUI) were processed by Ventana immunostaining method. Results: Both groups were compatible for age, BMI, and obstetric history. Positive ER-α and ER-β immunoreaction was observed in 46.4% and 3.6% of SUI (43.3% and 33.3 % of controls) (p < 0.05), respectively, and PR immunoreaction in 39.3% of SUI (46.7% of controls). Collagen I and III immunoreaction was observed in 28,6% and 21.4 % of SUI (30.% and 36.7% of controls), respectively, and elastin, decorin, and fibromodulin immunoreaction in 10.7 %, 10.7%, and 10.7% of SUI (50%, 33.3%, 33,.3% of controls) (p < 0.05), respectively. VIP immunoreaction was observed in 7.1% of SUI (36.7% of controls). Conclusion: Immunoexpression of ER-β, elastin, decorin, fibromodulin, and VIP was significantly lower in SUI than controls, showing that the ER-β dependent re-modeling of the extracellular matrix of vaginal tissues is the main mechanism of SUI.
Key words:  Incontinence      Hormones      Collagen      Elastin      Proteoglycans     
Published:  10 December 2016     
*Corresponding Author(s):  E. PANTATOSAKIS     E-mail:  epantatosakis@hotmail.com

Cite this article: 

E. Pantatosakis, D. Karandrea, E. Liapis, A. Kondi-Pafiti, A. Liapis. Immunohistochemical expression of hormonal receptors, collagen, elastin, and proteoglycans in genuine urinary incontinence. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 849-852.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3390.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I6/849

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